Gene Symbol | ERVFRD-1 |
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Entrez Gene | 405754 |
Alt Symbol | ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191, envFRD |
Species | Human |
Gene Type | protein-coding |
Description | endogenous retrovirus group FRD, member 1 |
Other Description | HERV-FRD provirus ancestral Env polyprotein|HERV-FRD_6p24.1 provirus ancestral Env polyprotein|endogenous retrovirus group FRD member 1|envelope polyprotein|syncytin 2|syncytin-2 |
Swissprots | P60508 |
Accessions | CAH68778 P60508 AK075092 BAC11396 AK123938 BAC85731 AY358244 AAQ88611 BC068585 AAH68585 DA863475 GQ129285 ACT64419 GQ129286 ACT64420 NM_207582 NP_997465 |
Function | This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732). {ECO:0000269|PubMed:18988732}. |
Subcellular Location | Virion {ECO:0000305}. |
Tissue Specificity | Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea. {ECO:0000269|PubMed:12970426}. |
syncytin-2 CRISPR/Cas9 KO Plasmid (h) - sc-416005 from Santa Cruz Biotechnology
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syncytin-2 HDR Plasmid (h) - sc-416005-HDR from Santa Cruz Biotechnology
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syncytin-2 Double Nickase Plasmid (h) - sc-416005-NIC from Santa Cruz Biotechnology
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syncytin-2 Double Nickase Plasmid (h2) - sc-416005-NIC-2 from Santa Cruz Biotechnology
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syncytin-2 CRISPR Activation Plasmid (h) - sc-416005-ACT from Santa Cruz Biotechnology
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syncytin-2 CRISPR Activation Plasmid (h2) - sc-416005-ACT-2 from Santa Cruz Biotechnology
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syncytin-2 Lentiviral Activation Particles (h) - sc-416005-LAC from Santa Cruz Biotechnology
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syncytin-2 Lentiviral Activation Particles (h2) - sc-416005-LAC-2 from Santa Cruz Biotechnology
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syncytin-2 siRNA (h) - sc-95207 from Santa Cruz Biotechnology
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syncytin-2 shRNA Plasmid (h) - sc-95207-SH from Santa Cruz Biotechnology
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syncytin-2 shRNA (h) Lentiviral Particles - sc-95207-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7980 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7980 from Sigma-Aldrich
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ERVFRD-1 siRNA (Human) - CRJ8193 from Cohesion Biosciences
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ERVFRD-1 - MBS8217435 from MyBioSource
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Human ERVFRD-1 siRNA - orb278694 from Biorbyt
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ERVFRD-1 shRNA Plasmid (Human) - CHJ8193 from Cohesion Biosciences
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ERVFRD-1 miRNA 3'UTR clone - MiUTR3H-11290 from Creative biogene
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