NLK

Gene Symbol	NLK
Entrez Gene	51701
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	nemo-like kinase
Other Description	serine/threonine-protein kinase NLK
Swissprots	Q2PNI9 Q6P2A3 B2RCX1 Q9UBE8
Accessions	ABC40748 EAW51060 EAW51061 EAW51062 EAW51063 Q9UBE8 AF180819 AAD56013 AF197898 AAF04857 AK024686 AK315315 BAG37718 AL036279 AL161970 BC064663 AAH64663 BM723604 BQ636970 DA224552 DA573077 U69562 XM_005257988 XP_005258045 XM_011524888 XP_011523190 XR_934482 NM_016231 NP_057315
Function	Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin tar
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). {ECO:0000250}.
Top Pathways	Wnt signaling pathway, Adherens junction, MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NLK full length protein - ab107700 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human NLK full length protein - ab162638 from Abcam Category Protein Source Wheat germ Species Human

Human NLK peptide - ab26986 from Abcam Category Peptide

Human NLK protein fragment - ab162639 from Abcam Category Protein Source Wheat germ Species Human

NLK-Antibody-C-term-Blocking-Peptide - BP7545b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human LAK1 protein - orb139399 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

NLK - H00051701-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NLK - H00051701-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NLK - H00051701-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NLK - H00051701-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NLK - P4735 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

NLK - P5734 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

NLK fusion protein - Ag6348 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NLK fusion protein - Ag5750 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NLK - NLK-28098TH from Creative Biomart Category Protein Source Baculovirus infected sf9 cells

Recombinant Human NLK, His & GST tagged - NLK-7318H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human NLK, His-tagged - NLK-1306H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NLK, GST-tagged - NLK-1066H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

NLK Protein, active, 250 µg - 14-676M from EMD Millipore Category Protein Prices $2,440.00 Sizes 250 µg also available in 10 μg size . (cat#14-676) and in bulk (cat#14-676-K) Source expressed by baculovirus in Sf21 cells

NLK Protein, active, 10 µg - 14-676 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

Recombinant Human Serine/threonine-protein kinase NLK(NLK) - CSB-YP890657HU CSB-EP890657HU CSB-BP890657HU CSB-MP890657HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NLK - TP308723 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human NLK Active GST-His - CRN004 from Cell Science Prices $1,795.00 Sizes 50 µg Source Baculovirus infected Sf9 cells Species Human

Recombinant Human NLK His - CSI13443 from Cell Science Prices $615.00 Sizes 10 μg Species Human

Recombinant Human PAK1 Active GST-His - CRP031 from Cell Science Prices $1,795.00 Sizes 50 µg Source Baculovirus infected Sf9 cells Species Human

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