| Gene Symbol |
Hsd11b1
|
| Entrez Gene |
100135542
|
| Alt Symbol |
-
|
| Species |
Guinea Pig
|
| Gene Type |
protein-coding
|
| Description |
hydroxysteroid 11-beta dehydrogenase 1
|
| Other Description |
11-DH|11-beta-HSD1|11-beta-hydroxysteroid dehydrogenase 1|11-beta-hydroxysteroid dehydrogenase type 1|corticosteroid 11-beta-dehydrogenase isozyme 1|hydroxysteroid (11-beta) dehydrogenase 1
|
| Swissprots |
Q9QZE1 Q6QLL4
|
| Accessions |
Q6QLL4 AF188005 AAF01249 AY535424 AAS47491 NM_001172857 NP_001166328
|
| Function |
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10699594}; Single-pass type II membrane protein {ECO:0000269|PubMed:10699594}.
|
| Tissue Specificity |
Widely expressed at low levels. Highest expression in liver. {ECO:0000269|PubMed:10699594}.
|