| Gene Symbol |
SS18L1
|
| Entrez Gene |
26039
|
| Alt Symbol |
CREST, LP2261
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synovial sarcoma translocation gene on chromosome 18-like 1
|
| Other Description |
SS18-like protein 1|SYT homolog 1|calcium-responsive transactivator
|
| Swissprots |
A8K620 B3KWR8 Q8NE69 E1P5H7 A6NNE3 Q6XYD9 Q5JXJ3 Q6MZV9 Q9BR55 Q9H4K6 O75177 Q6NTH3
|
| Accessions |
EAW75389 EAW75390 EAW75391 EAW75392 EAW75393 EAW75394 EAW75395 EAW75396 O75177 AB014593 BAA31668 AK125656 BAG54230 AK291485 BAF84174 AK299881 BAG61729 AK308765 AY203931 AAP34454 BC034494 AAH34494 BC068993 AAH68993 BX640848 CAE45918 DC375156 DQ890908 ABM81834 EU176499 ABW03300 XM_005260389 XP_005260446 XM_005260391 XP_005260448 XM_011528764 XP_011527066 XM_011528765 XP_011527067 XM_011528766 XP_011527068 XM_011528767 XP_011527069 NM_001301778 NP_001288707 NM_198935 NP_945173 NR_125980 NR_125981 NM_015558
|
| Function |
Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGOL1 at kinetochore (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous; with lowest levels in spleen.
|