SS18L1

Gene Symbol SS18L1
Entrez Gene 26039
Alt Symbol CREST, LP2261
Species Human
Gene Type protein-coding
Description synovial sarcoma translocation gene on chromosome 18-like 1
Other Description SS18-like protein 1|SYT homolog 1|calcium-responsive transactivator
Swissprots A8K620 B3KWR8 Q8NE69 E1P5H7 A6NNE3 Q6XYD9 Q5JXJ3 Q6MZV9 Q9BR55 Q9H4K6 O75177 Q6NTH3
Accessions EAW75389 EAW75390 EAW75391 EAW75392 EAW75393 EAW75394 EAW75395 EAW75396 O75177 AB014593 BAA31668 AK125656 BAG54230 AK291485 BAF84174 AK299881 BAG61729 AK308765 AY203931 AAP34454 BC034494 AAH34494 BC068993 AAH68993 BX640848 CAE45918 DC375156 DQ890908 ABM81834 EU176499 ABW03300 XM_005260389 XP_005260446 XM_005260391 XP_005260448 XM_011528764 XP_011527066 XM_011528765 XP_011527067 XM_011528766 XP_011527068 XM_011528767 XP_011527069 NM_001301778 NP_001288707 NM_198935 NP_945173 NR_125980 NR_125981 NM_015558
Function Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGOL1 at kinetochore (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous; with lowest levels in spleen.

CREST CRISPR/Cas9 KO Plasmid (h) - sc-403134 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST HDR Plasmid (h) - sc-403134-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST Double Nickase Plasmid (h) - sc-403134-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST Double Nickase Plasmid (h2) - sc-403134-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST CRISPR Activation Plasmid (h) - sc-403134-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST CRISPR Activation Plasmid (h2) - sc-403134-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST Lentiviral Activation Particles (h) - sc-403134-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST Lentiviral Activation Particles (h2) - sc-403134-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CREST siRNA (h) - sc-60441 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CREST shRNA Plasmid (h) - sc-60441-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CREST shRNA (h) Lentiviral Particles - sc-60441-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU157901 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20612 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20612 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SS18L1 siRNA (Human) - CRH8672 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SS18L1 - MBS8205793 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SS18L1 (NM_198935.1) - SHH418320 from Creative biogene

Category siRNA
Species Reactivities Human

Human SS18L1 siRNA - orb269174 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SS18L1 shRNA Plasmid (Human) - CHH8672 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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