| Gene Symbol |
ERCC5
|
| Entrez Gene |
2073
|
| Alt Symbol |
COFS3, ERCC5-201, ERCM2, UVDR, XPG, XPGC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 5
|
| Other Description |
DNA excision repair protein ERCC-5|DNA repair protein complementing XP-G cells|XPG-complementing protein|excision repair cross-complementing rodent repair deficiency, complementation group 5|xeroderma pigmentosum, complementation group G
|
| Swissprots |
Q9HD60 Q9HD59 P28715 Q8N1B7 Q5JUS5 Q8IZL6 A6NGT4 Q7Z2V3 Q5JUS4
|
| Accessions |
AAF89177 AAF89178 AAF89179 AAN46091 CAA50481 EAX09071 EAX09072 P28715 AF462447 AAP97715 AK294708 BAG57863 AK299758 BAG61647 AK303558 BAG64582 BC031522 AAH31522 BE223050 BQ002437 BQ707436 BX647399 D16305 BAA03812 DA195001 DQ891818 ABM82744 DQ895006 ABM85932 L20046 AAC37533 LM994821 CDY80174 X69978 CAA49598 NM_000123 NP_000114
|
| Function |
Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:7651464}.
|
| Top Pathways |
Nucleotide excision repair
|
![Western Blot: XPG Overexpression Lysate (Adult Normal) [NBL1-10323] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for XPG.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7870_XPG%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10323-img0002.jpg)