MAPK12

Gene Symbol MAPK12
Entrez Gene 6300
Alt Symbol ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 12
Other Description MAP kinase 12|MAP kinase p38 gamma|extracellular signal-regulated kinase 6|mitogen-activated protein kinase 3|mitogen-activated protein kinase p38 gamma|stress-activated protein kinase 3
Swissprots Q6IC53 P53778 Q99588 Q14260 Q99672
Accessions EAW73521 EAW73522 P53778 AK098058 BAG53571 AK123665 BAG53932 AK289770 BAF82459 AK294422 BAH11760 AK307421 AK307724 AK308768 BC015741 AAH15741 BX640648 CAE45794 CB123561 CR456515 CAG30401 CU013115 CAK54546 CU013403 CAK54845 DQ892787 ABM83713 DQ896034 ABM87033 U66243 AAB40118 X79483 CAA55984 Y10487 CAA71511 NM_001303252 NP_001290181 NM_002969 NP_002960
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1,
Subcellular Location Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11991731, ECO:0000269|PubMed:8633070}.
Top Pathways Proteoglycans in cancer, Retrograde endocannabinoid signaling, Sphingolipid signaling pathway, Rap1 signaling pathway, Epstein-Barr virus infection

p38γ MAPK Antibody - 2307 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of purified recombinant full-length p38 MAPK GST fusion protein, using p38 MAP kinase pan antibody (upper) or p38γ MAPK Antibody (lower).

p38γ (E-4) - sc-398546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38γ (E-4): sc-398546. Western blot analysis of p38γ expression in non-transfected: sc-117752 (A) and mouse p38γ transfected: sc-122318 (B) 293T whole cell lysates.

p38γ (E-11) - sc-365487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38γ (E-11): sc-365487. Western blot analysis of p38γ expression in non-transfected: sc-117752 (A) and mouse p38γ transfected: sc-122318 (B) 293T whole cell lysates.

p38γ (E-5) - sc-365550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38γ (E-5): sc-365550. Western blot analysis of p38γ expression in non-transfected: sc-117752 (A) and mouse p38γ transfected: sc-122318 (B) 293T whole cell lysates.

p38γ (C-16) - sc-6022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p38γ (C-16): sc-6022. Immunofluorescence staining of methanol-fixed Sol8 cells showing cytoplasmic localization.

p38γ (G5F3) - sc-33690 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38γ (G5F3): sc-33690. Western blot analysis of human recombinant p38γ.

p38γ (H-57) - sc-366013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p38γ (H-57): sc-366013. Western blot analysis of p38γ expression in non-transfected 293T: sc-117752 (A), mouse p38γ transfected 293T: sc-122318 (B) and PC-12 (C) whole cell lysates and mouse skeletal muscle tissue extract (D).

p38γ (N-19) - sc-6023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p38γ (N-19): sc-6023. Western blot analysis of p38γ expression in non-transfected: sc-117752 (A) and mouse p38γ transfected: sc-122318 (B) 293T whole cell lysates.

Anti-SAPK3 antibody - ab37932 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SAPK3 antibody (ab37932) at 1/100 dilution + mouse muscle tissue lysateSecondaryHRP-anti-rabbit developed using the ECL technique

Anti-SAPK3 antibody [10E1] - ab117985 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10E1
All lanes : Anti-SAPK3 antibody [10E1] (ab117985) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SAPK3 cDNA

Anti-SAPK3 antibody [MM0506-8J21] - ab89898 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0506-8J21

Anti-SAPK3 antibody [R12-L], prediluted (FITC) - ab183199 from Abcam

Prices $370.00
Sizes 50 tests
Host Rabbit
Clonality Monoclonal
Clone R12-L
Flow cytometric analysis of permeabilized Hek293 cells labeling SAPK4 with ab183199 at 10μl/ test (blue) compared with an isotype control (black).

Anti-SAPK3 antibody [R13-L] - C-terminal - ab183210 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone R13-L
Immunofluorescent analysis of HEK293 cells labeling SAPK3 with ab183210 at 1/300 dilution.

Anti-SAPK3 antibody - C-terminal - ab166665 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAPK3 antibody - C-terminal (ab166665) at 1/1000 dilutionLane 1 : HeLa whole cell extractLane 2 : Jurkat whole cell extract

Anti-MAPK12 / ERK6 / SAPK3 Antibody (aa289-338) - LS-C135387 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAPK12 / ERK5 antibody LS-C135387 Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml.

Anti-MAPK12 / ERK6 / SAPK3 Antibody (clone 1G4) - LS-C133423 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G4
Detection limit for recombinant GST tagged MAPK12 is approximately 0.3 ng/ml as a capture antibody.

Anti-MAPK12 / ERK6 / SAPK3 Antibody (aa35-84) - LS-C107534 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAPK12 / ERK5 antibody LS-C107534 Western blot of Jurkat lysate.

Anti-MAPK12 / ERK6 / SAPK3 Antibody - LS-C188807 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (C-Terminus) - LS-C188809 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (aa314-363) - LS-C206173 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (Internal, AP) - LS-C219993 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (Internal, Biotin) - LS-C219995 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (Internal, APC) - LS-C219994 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (Internal, FITC) - LS-C219996 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK12 / ERK6 / SAPK3 Antibody (Internal, PE) - LS-C219998 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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