MAPK12

Gene Symbol	MAPK12
Entrez Gene	6300
Alt Symbol	ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 12
Other Description	MAP kinase 12|MAP kinase p38 gamma|extracellular signal-regulated kinase 6|mitogen-activated protein kinase 3|mitogen-activated protein kinase p38 gamma|stress-activated protein kinase 3
Swissprots	Q6IC53 P53778 Q99588 Q14260 Q99672
Accessions	EAW73521 EAW73522 P53778 AK098058 BAG53571 AK123665 BAG53932 AK289770 BAF82459 AK294422 BAH11760 AK307421 AK307724 AK308768 BC015741 AAH15741 BX640648 CAE45794 CB123561 CR456515 CAG30401 CU013115 CAK54546 CU013403 CAK54845 DQ892787 ABM83713 DQ896034 ABM87033 U66243 AAB40118 X79483 CAA55984 Y10487 CAA71511 NM_001303252 NP_001290181 NM_002969 NP_002960
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1,
Subcellular Location	Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11991731, ECO:0000269|PubMed:8633070}.
Top Pathways	Proteoglycans in cancer, Retrograde endocannabinoid signaling, Sphingolipid signaling pathway, Rap1 signaling pathway, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® p38γ MAPK siRNA I - 6632 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence® p38γ MAPK siRNA II - 6633 from Cell Signaling Technology Category siRNA

p38γ CRISPR/Cas9 KO Plasmid (h) - sc-400427 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ HDR Plasmid (h) - sc-400427-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ Double Nickase Plasmid (h) - sc-400427-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ Double Nickase Plasmid (h2) - sc-400427-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ CRISPR Activation Plasmid (h) - sc-400427-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ CRISPR Activation Plasmid (h2) - sc-400427-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ Lentiviral Activation Particles (h) - sc-400427-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ Lentiviral Activation Particles (h2) - sc-400427-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p38γ siRNA (h) - sc-39013 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38γ shRNA Plasmid (h) - sc-39013-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38γ shRNA (h) Lentiviral Particles - sc-39013-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38γ siRNA (h2) - sc-39118 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38γ shRNA Plasmid (h2) - sc-39118-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38γ shRNA (h2) Lentiviral Particles - sc-39118-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p38 gamma/SAPK3 RNAi - H00006300-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU008971 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1195 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1197 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1196 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1558 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1559 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1558 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1559 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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