MAPK12

Gene Symbol	MAPK12
Entrez Gene	6300
Alt Symbol	ERK-6, ERK3, ERK6, MAPK 12, P38GAMMA, PRKM12, SAPK-3, SAPK3
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 12
Other Description	MAP kinase 12|MAP kinase p38 gamma|extracellular signal-regulated kinase 6|mitogen-activated protein kinase 3|mitogen-activated protein kinase p38 gamma|stress-activated protein kinase 3
Swissprots	Q6IC53 P53778 Q99588 Q14260 Q99672
Accessions	EAW73521 EAW73522 P53778 AK098058 BAG53571 AK123665 BAG53932 AK289770 BAF82459 AK294422 BAH11760 AK307421 AK307724 AK308768 BC015741 AAH15741 BX640648 CAE45794 CB123561 CR456515 CAG30401 CU013115 CAK54546 CU013403 CAK54845 DQ892787 ABM83713 DQ896034 ABM87033 U66243 AAB40118 X79483 CAA55984 Y10487 CAA71511 NM_001303252 NP_001290181 NM_002969 NP_002960
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1,
Subcellular Location	Cytoplasm. Nucleus. Mitochondrion. Note=Mitochondrial when associated with SH3BP5. In skeletal muscle colocalizes with SNTA1 at the neuromuscular junction and throughout the sarcolemma (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11991731, ECO:0000269|PubMed:8633070}.
Top Pathways	Proteoglycans in cancer, Retrograde endocannabinoid signaling, Sphingolipid signaling pathway, Rap1 signaling pathway, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SAPK3 full length protein - ab125651 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human SAPK3 full length protein - ab117221 from Abcam Category Protein Source E. coli Species Human

Human SAPK3 full length protein - ab45160 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

MAPK12 / ERK6 / SAPK3 Antibody Blocking Peptide - LS-E20543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK12 / ERK6 / SAPK3 Antibody Blocking Peptide - LS-E20542 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK12 / ERK6 / SAPK3 Antibody Blocking Peptide - LS-E8780 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK12 / ERK6 / SAPK3 Antibody Blocking Peptide - LS-E9016 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

p38 gamma/SAPK3 Recombinant Protein - H00006300-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 gamma/SAPK3 Partial Recombinant Protein - H00006300-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

p38 gamma/SAPK3 Recombinant Protein - P3878 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

p38 gamma/SAPK3 Recombinant Protein - P4739 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human p38 gamma/SAPK3 Protein - NBP1-72551 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

p38 gamma/SAPK3 Peptide - P2392 from Novus Biologicals Category Peptide Species Human

p38 gamma/SAPK3 Peptide - P2513 from Novus Biologicals Category Peptide Species Human

MAPK12-Antibody-Center-Blocking-Peptide - BP7224c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPK12-Antibody-C-term-Blocking-peptide - BP7511a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ERK1 (Active) recombinant protein - GTX65218 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Human MAPK12 protein - orb168774 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

ERK3 (GST Tag) protein - orb171523 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human MAPK12 protein - orb139316 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

MAPK12 peptide - orb217908 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse

MAPK12 Blocking Peptide - 33R-8447 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Mapk12 Blocking Peptide - 33R-2707 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAPK12 protein (His tag) - 80R-2055 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

SAPK3 Blocking Peptide - abx063239 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

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