SH2B1

Gene Symbol SH2B1
Entrez Gene 25970
Alt Symbol PSM, SH2B
Species Human
Gene Type protein-coding
Description SH2B adaptor protein 1
Other Description SH2 domain-containing protein 1B|SH2 domain-containing putative adapter SH2-B|SH2-B signaling protein|SH2B adapter protein 1|pro-rich, PH and SH2 domain-containing signaling mediator
Swissprots Q9NRF1 Q9Y3Y3 Q96FK3 Q9NRF2 Q9P2P7 Q9NRF3 Q96SX3 A8K2R7
Accessions EAW51999 EAW52000 EAW52001 EAW52002 EAW52003 EAW52004 EAW52005 Q9NRF2 AB037720 BAA92537 AF227967 AAF73912 AF227968 AAF73913 AF227969 AAF73914 AK027488 BAB55148 AK055104 BAG51467 AK290332 BAF83021 AK297080 BAG59597 AK298569 BAG60762 AL049924 CAB43208 AL713760 CAD28530 BC010704 AAH10704 DA338190 DA490578 DB026545 XM_005255240 XP_005255297 XM_006721031 XP_006721094 XM_006721032 XP_006721095 XM_006721033 XP_006721096 XM_006721034 XP_006721097 XM_006721037 XP_006721100 XM_011545787 XP_011544089 XM_011545788 XP_011544090 XR_950774 NM_001145795 NP_001139267 NM_001145796 NP_001139268 NM_001145797 NP_001139269 NM_001145812 NP_001139284 NM_001308293 NP_001295222 NM_001308294 NP_001295223 NM_015503 NP_056318
Function Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin,
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in skeletal muscle and ovary. {ECO:0000269|PubMed:15767667}.
Top Pathways Neurotrophin signaling pathway

SH2-B (E-8) - sc-393395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH2-B (E-8): sc-393395. Western blot analysis of SH2-B expression in SJRH30 (A), ES-2 (B) and OV-90 (C) whole cell lysates.

SH2-B (H-89) - sc-366009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SH2-B (H-89): sc-366009. Western blot analysis of SH2-B expression in SJRH30 (A), ES-2 (B) and OV-90 (C) whole cell lysates.

SH2-B α/β/γ/δ (G-17) - sc-8895 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH2-B α/β/γ/δ (G-17): sc-8895. Western blot analysis of SH2-B expression in non-transfected: sc-117752 (A) and mouse SH2-B transfected: sc-127534 (B) 293T whole cell lysates.

SH2-B α/β/γ (E-20) - sc-10827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SH2-B α/β/γ (E-20): sc-10827. Immunoperoxidase staining of formalin fixed, paraffin-embedded human ovary tissue showing cytoplasmic and nuclear staining of ovarian stroma cells.

SH2-B α/β/γ/δ (46) - sc-136065 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SH2-B α/β/γ/δ (46): sc-136065. Western blot analysis of SH2-B α/β/γ/δ expression in SW-13 whole cell lysate.

SH2-B α/β/γ/δ (C-11) - sc-514142 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SH2-B α/β/γ/δ (C-11): sc-514142. Western blot analysis of SH2-B α/β/γ/δ expression in SJRH30 whole cell lysate.

Anti-SH2B1 antibody - ab169011 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-SH2B1 antibody (ab169011) at 1/500 dilution + Human kidney lysate at 15 µl

Anti-SH2B1 antibody - ab196575 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U20S cells labeling SH2B1 with ab196575 at a 1/50 dilution. Blue: DAPI for nuclear staining.

Anti-SH2B1 antibody - ab123562 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SH2B1 antibody (ab123562) at 1/100 dilution + 293 cell line lyates at 35 µg

Anti-SH2B1 antibody - ab89230 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-SH2B1 antibody (ab89230) at 1 µg/ml + Human kidney tissue lysate at 50 µg

Anti-SH2B1 antibody - ab172464 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SH2B1 antibody (ab172464) at 1 µg/mlLane 1 : SH2B1 transfected 293T cell lysateLane 2 : Non-transfected cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-SH2B1 antibody - ab57161 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57161 SH2B antibody at 1ug/ml.

Anti-SH2B1 Antibody - LS-C334143 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach using SH2B1 antibody at dilution of 1:200 (x400 lens)

Anti-SH2B1 Antibody (aa395-444) IHC-plus™ - LS-B5863 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SH2B1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5863 concentration 5 ug/ml.

Anti-SH2B1 Antibody (aa414-426) - LS-C55459 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SH2B1 Antibody (C-Terminus) - LS-C132086 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SH2B1 Antibody (aa744-756) - LS-C132087 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, AP) - LS-C224052 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, APC) - LS-C224053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, Biotin) - LS-C224054 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, FITC) - LS-C224055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, Azide-free, HRP) - LS-C224056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752) - LS-C325074 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody (aa724-752, PE) - LS-C224057 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SH2B1 Antibody - LS-C341658 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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