| Gene Symbol |
SH2B1
|
| Entrez Gene |
25970
|
| Alt Symbol |
PSM, SH2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH2B adaptor protein 1
|
| Other Description |
SH2 domain-containing protein 1B|SH2 domain-containing putative adapter SH2-B|SH2-B signaling protein|SH2B adapter protein 1|pro-rich, PH and SH2 domain-containing signaling mediator
|
| Swissprots |
Q9NRF1 Q9Y3Y3 Q96FK3 Q9NRF2 Q9P2P7 Q9NRF3 Q96SX3 A8K2R7
|
| Accessions |
EAW51999 EAW52000 EAW52001 EAW52002 EAW52003 EAW52004 EAW52005 Q9NRF2 AB037720 BAA92537 AF227967 AAF73912 AF227968 AAF73913 AF227969 AAF73914 AK027488 BAB55148 AK055104 BAG51467 AK290332 BAF83021 AK297080 BAG59597 AK298569 BAG60762 AL049924 CAB43208 AL713760 CAD28530 BC010704 AAH10704 DA338190 DA490578 DB026545 XM_005255240 XP_005255297 XM_006721031 XP_006721094 XM_006721032 XP_006721095 XM_006721033 XP_006721096 XM_006721034 XP_006721097 XM_006721037 XP_006721100 XM_011545787 XP_011544089 XM_011545788 XP_011544090 XR_950774 NM_001145795 NP_001139267 NM_001145796 NP_001139268 NM_001145797 NP_001139269 NM_001145812 NP_001139284 NM_001308293 NP_001295222 NM_001308294 NP_001295223 NM_015503 NP_056318
|
| Function |
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin,
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with highest levels in skeletal muscle and ovary. {ECO:0000269|PubMed:15767667}.
|
| Top Pathways |
Neurotrophin signaling pathway
|
