SH2B1

Gene Symbol	SH2B1
Entrez Gene	25970
Alt Symbol	PSM, SH2B
Species	Human
Gene Type	protein-coding
Description	SH2B adaptor protein 1
Other Description	SH2 domain-containing protein 1B|SH2 domain-containing putative adapter SH2-B|SH2-B signaling protein|SH2B adapter protein 1|pro-rich, PH and SH2 domain-containing signaling mediator
Swissprots	Q9NRF1 Q9Y3Y3 Q96FK3 Q9NRF2 Q9P2P7 Q9NRF3 Q96SX3 A8K2R7
Accessions	EAW51999 EAW52000 EAW52001 EAW52002 EAW52003 EAW52004 EAW52005 Q9NRF2 AB037720 BAA92537 AF227967 AAF73912 AF227968 AAF73913 AF227969 AAF73914 AK027488 BAB55148 AK055104 BAG51467 AK290332 BAF83021 AK297080 BAG59597 AK298569 BAG60762 AL049924 CAB43208 AL713760 CAD28530 BC010704 AAH10704 DA338190 DA490578 DB026545 XM_005255240 XP_005255297 XM_006721031 XP_006721094 XM_006721032 XP_006721095 XM_006721033 XP_006721096 XM_006721034 XP_006721097 XM_006721037 XP_006721100 XM_011545787 XP_011544089 XM_011545788 XP_011544090 XR_950774 NM_001145795 NP_001139267 NM_001145796 NP_001139268 NM_001145797 NP_001139269 NM_001145812 NP_001139284 NM_001308293 NP_001295222 NM_001308294 NP_001295223 NM_015503 NP_056318
Function	Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin,
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
Tissue Specificity	Widely expressed with highest levels in skeletal muscle and ovary. {ECO:0000269|PubMed:15767667}.
Top Pathways	Neurotrophin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SH2B1 full length protein - ab161849 from Abcam Category Protein Source Wheat germ Species Human

Human SH2B1 protein fragment - ab161850 from Abcam Category Protein Source Wheat germ Species Human

SH2B1 Antibody Blocking Peptide - LS-E3823 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH2B1 Antibody Blocking Peptide - LS-E19955 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SH2B1 Protein - H00025970-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SH2B1 Recombinant Protein - H00025970-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SH2B1-Antibody-C-term-Blocking-Peptide - BP16002b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SH2-B/SH2B1 blocking peptide - GTX89776-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Goat anti SH2B1 antibody Immunizing peptide - orb15748 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

SH2B1 Blocking Peptide - 33R-3617 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SH2B1 Peptide - AC21-0048-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SH2B1 / SH2B - H00025970-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SH2B1 / SH2B - H00025970-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SH2B1 / SH2B - H00025970-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SH2B1 / SH2B - H00025970-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SH2B1 Peptide - 46-364P from ProSci Category Peptide

SH2B1 fusion protein - ag2863 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SH2B adapter protein 1(SH2B1) - CSB-YP868300HU CSB-EP868300HU CSB-BP868300HU CSB-MP868300HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SH2-B/SH2B1, Peptide - MBS425978 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

SH2B1-Antibody-Center-Blocking-Peptide - BP9823c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SH2B1 Peptide, Human - M34GP14153H from Creative Peptides Category Peptide Source Synthetic. Species Human

SH2B adapter protein 1 (SH2B1), Recombinant Protein - MBS1433632 from MyBioSource Category Protein Prices $1,570.00, $1,570.00, $1,800.00, $1,800.00, $2,705.00, $2,705.00, $3,150.00, $3,150.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SH2B1 Recombinant Protein Antigen - NBP2-56004PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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