UVSSA

Gene Symbol	UVSSA
Entrez Gene	57654
Alt Symbol	KIAA1530, UVSS3
Species	Human
Gene Type	protein-coding
Description	UV-stimulated scaffold protein A
Other Description	-
Swissprots	Q8WTX4 Q2YD98 A8K9E6 Q9P1Z8 B2RU11
Accessions	EAW82584 Q2YD98 AB040963 BAA96054 AK292661 BAF85350 AL110229 AL390128 CAH10662 AL512751 BC021930 AAH21930 BC110331 AAI10332 BC140901 AAI40902 EL735271 HG496660 XM_005272290 XP_005272347 XM_006713897 XP_006713960 XM_011513519 XP_011511821 XM_011513520 XP_011511822 XM_011513521 XP_011511823 XM_011513522 XP_011511824 XM_011513523 XP_011511825 XM_011513524 XP_011511826 XM_011513525 XP_011511827 XM_011513526 XP_011511828 XM_011513527 XP_011511829 XM_011513528 XP_011511830 XM_011513529 XP_011511831 XM_011513530 XP_011511832 XM_011513531 XP_011511833 XM_011513532 XP_011511834 XM_011513533 XP_011511835 XM_011513534 XP_011511836 XM_011513535 XP_011511837 XM_011513536 XP_011511838 XM_011513537 XP_011511839 XM_011513538 XP_011511840 XR_924979 XR_924981 XR_924982 XR_924984 XR_924985 NM_020894 NP_065945
Function	Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. {ECO:0000269\|PubMed:22466610, ECO:0000269\|PubMed:22466611, ECO:0000269\|PubMed:22466612}.
Subcellular Location	Chromosome {ECO:0000269\|PubMed:22466611, ECO:0000269\|PubMed:22466612}. Note=Accumulates at UV DNA damage sites.

KIAA1530 (P-12) - sc-138374 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

KIAA1530 (P-12): sc-138374. Western blot analysis of KIAA1530 expression in Y79 (A), MOLT-4 (B), Raji (C) whole cell lysates.

KIAA1530 (S-12) - sc-138375 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

KIAA1530 (S-12): sc-138375. Western blot analysis of KIAA1530 expression in non-transfected: sc-117752 (A) and human KIAA1530 transfected: sc-111962 (B) 293T whole cell lysates.

Anti-KIAA1530 antibody - ab167215 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-KIAA1530 antibody (ab167215) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with KIAA1530Lane 2 : Non-transfected 293T cell lysate

Anti-KIAA1530 antibody - ab188042 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human stomach, lower tissue labeling KIAA1530 with ab188042 at 1/200 dilution.

Anti-KIAA1530 antibody - N-terminal - ab137644 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence analysis of paraformaldehyde fixed A431 cells, labelling KIAA1530 with ab137644 at 1/200 dilution (left), costained with Hoechst 33342 (right).

Anti-KIAA1530 Antibody (C-Terminus) - LS-C345547 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of UVSSA Antibody with human Lymph Node Tumor lysate.

UVSSA Antibody - NBP1-32598 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

UVSSA Antibody - H00057654-B01P from Novus Biologicals

Prices	$349.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: UVSSA Antibody [H00057654-B01P] - Transfected 293T cell line. Lane 1: KIAA1530 transfected lysate(28.6 KDa). Lane 2: Non-transfected lysate.

Anti-UVSSA antibody produced in rabbit - HPA050824 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-UVSSA: <B>Cat. No. HPA050824</B>: Immunohistochemical staining of human stomach, lower shows moderate nuclear positivity in glandular cells.

Anti-KIAA1530 (N-terminal) antibody produced in rabbit - SAB2700336 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti-KIAA1530 (N-terminal): <B>Cat. No. SAB2700336</B>: Immunofluorescence analysis of paraformaldehyde-fixed A431, using KIAA1530 antibody at 1:200 dilution.

UVSSA Antibody - C-terminal region (ARP57482_P050) - ARP57482_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

KIAA1530 antibody - 25054-1-AP from Acris Antibodies

Prices	$270.00
Sizes	150 µl
Host	Rabbit
Clonality	Polyclonal

Raji cells were subjected to SDS PAGE followed by western blot with 25054-1-AP( KIAA1530 Antibody) at dilution of 1:300

KIAA1530 antibody - H00057654-B01P from Acris Antibodies

Prices	$360.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

KIAA1530 antibody - 25054-1-AP from Proteintech Group

Prices	$279.00
Sizes	con: 60 μg/150μl
Host	Rabbit
Clonality	Polyclonal

UVSSA - MBS273021 from MyBioSource

Prices	$360.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Sample(30 ug whole cell lysate) A: 293T B: A431 C: H1299 D: HeLa S3 E: Hep G2 F: MOLT4 G: Raji 7.5% SDS PAGE diluted at 1:1000

Anti-KIAA1530 (aa 1-192) polyclonal antibody - DPABH-00685 from Creative Diagnostics

Host	Rabbit
Clonality	Polyclonal

Anti-KIAA1530 (full length) polyclonal antibody - DPABH-06422 from Creative Diagnostics

Host	Mouse
Clonality	Polyclonal

KIAA1530 Polyclonal Antibody - PA5-28497 from Thermo Fisher Scientific

Prices	$349.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunofluorescent analysis of KIAA1530 in paraformaldehyde-fixed A431 cells using a KIAA1530 polyclonal antibody (Product # PA5-28497) at a 1:200 dilution.

Anti-KIAA1530 antibody produced in mouse - SAB1411754 from Sigma-Aldrich

Prices	$357.50
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-KIAA1530: <B>Cat. No. SAB1411754</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~28.6 kDa using KIAA1530 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

UVSSA Antibody - NBP2-48981 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: UVSSA Antibody [NBP2-48981] - Staining of human stomach, lower shows moderate nuclear positivity in glandular cells.

Monoclonal Anti-UVSSA antibody produced in mouse - SAB2702264 from Sigma-Aldrich

Prices	$320.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	GT816

<B>Immunoblotting</B><BR/>Monoclonal Anti-UVSSA: <B>Cat. No. SAB2702264</B>: UVSSA antibody detects UVSSA protein by Western blot analysis<BR/>A. 30 μg HeLa whole cell lysate/extract; 7.5 % SDS-PAGE; UVSSA antibody dilution: 1:500

UVSSA antibody - orb324334 from Biorbyt

Prices	$502.00
Sizes	100 μl
Host	Rabbit
Clonality	Polyclonal

anti-KIAA1530 antibody - A004545 from Biobool

Host	Rabbit
Clonality	Polyclonal

Anti-UVSSA Antibody A09174 - A09174 from Boster Bio

Prices	$299.00
Sizes	1
Host	Rabbit
Clonality	Polyclonal

UVSSA Antibody - NBP2-55432 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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