UVSSA

Gene Symbol UVSSA
Entrez Gene 57654
Alt Symbol KIAA1530, UVSS3
Species Human
Gene Type protein-coding
Description UV-stimulated scaffold protein A
Other Description -
Swissprots Q8WTX4 Q2YD98 A8K9E6 Q9P1Z8 B2RU11
Accessions EAW82584 Q2YD98 AB040963 BAA96054 AK292661 BAF85350 AL110229 AL390128 CAH10662 AL512751 BC021930 AAH21930 BC110331 AAI10332 BC140901 AAI40902 EL735271 HG496660 XM_005272290 XP_005272347 XM_006713897 XP_006713960 XM_011513519 XP_011511821 XM_011513520 XP_011511822 XM_011513521 XP_011511823 XM_011513522 XP_011511824 XM_011513523 XP_011511825 XM_011513524 XP_011511826 XM_011513525 XP_011511827 XM_011513526 XP_011511828 XM_011513527 XP_011511829 XM_011513528 XP_011511830 XM_011513529 XP_011511831 XM_011513530 XP_011511832 XM_011513531 XP_011511833 XM_011513532 XP_011511834 XM_011513533 XP_011511835 XM_011513534 XP_011511836 XM_011513535 XP_011511837 XM_011513536 XP_011511838 XM_011513537 XP_011511839 XM_011513538 XP_011511840 XR_924979 XR_924981 XR_924982 XR_924984 XR_924985 NM_020894 NP_065945
Function Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. {ECO:0000269|PubMed:22466610, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612}.
Subcellular Location Chromosome {ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612}. Note=Accumulates at UV DNA damage sites.

KIAA1530 CRISPR/Cas9 KO Plasmid (h) - sc-408933 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 HDR Plasmid (h) - sc-408933-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 Double Nickase Plasmid (h) - sc-408933-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 Double Nickase Plasmid (h2) - sc-408933-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 CRISPR Activation Plasmid (h) - sc-408933-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 CRISPR Activation Plasmid (h2) - sc-408933-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 Lentiviral Activation Particles (h) - sc-408933-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 Lentiviral Activation Particles (h2) - sc-408933-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KIAA1530 siRNA (h) - sc-89002 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA1530 shRNA Plasmid (h) - sc-89002-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KIAA1530 shRNA (h) Lentiviral Particles - sc-89002-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU015541 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11138 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11138 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10775 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10775

UVSSA siRNA (Human) - CRJ1609 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UVSSA - MBS8208581 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KIAA1530 (NM_020894.2) - SHH324811 from Creative biogene

Category siRNA
Species Reactivities Human

UVSSA shRNA Plasmid (Human) - CHJ1609 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UVSSA miRNA 3'UTR clone - MiUTR4H-TG11584 from Creative biogene

Species Reactivities Human
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