UVSSA

Gene Symbol	UVSSA
Entrez Gene	57654
Alt Symbol	KIAA1530, UVSS3
Species	Human
Gene Type	protein-coding
Description	UV-stimulated scaffold protein A
Other Description	-
Swissprots	Q8WTX4 Q2YD98 A8K9E6 Q9P1Z8 B2RU11
Accessions	EAW82584 Q2YD98 AB040963 BAA96054 AK292661 BAF85350 AL110229 AL390128 CAH10662 AL512751 BC021930 AAH21930 BC110331 AAI10332 BC140901 AAI40902 EL735271 HG496660 XM_005272290 XP_005272347 XM_006713897 XP_006713960 XM_011513519 XP_011511821 XM_011513520 XP_011511822 XM_011513521 XP_011511823 XM_011513522 XP_011511824 XM_011513523 XP_011511825 XM_011513524 XP_011511826 XM_011513525 XP_011511827 XM_011513526 XP_011511828 XM_011513527 XP_011511829 XM_011513528 XP_011511830 XM_011513529 XP_011511831 XM_011513530 XP_011511832 XM_011513531 XP_011511833 XM_011513532 XP_011511834 XM_011513533 XP_011511835 XM_011513534 XP_011511836 XM_011513535 XP_011511837 XM_011513536 XP_011511838 XM_011513537 XP_011511839 XM_011513538 XP_011511840 XR_924979 XR_924981 XR_924982 XR_924984 XR_924985 NM_020894 NP_065945
Function	Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. {ECO:0000269|PubMed:22466610, ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612}.
Subcellular Location	Chromosome {ECO:0000269|PubMed:22466611, ECO:0000269|PubMed:22466612}. Note=Accumulates at UV DNA damage sites.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KIAA1530 full length protein - ab163620 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human UVSSA Protein - H00057654-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KIAA1530-Antibody-N-term-Blocking-Peptide - BP10583a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KIAA1530 - H00057654-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KIAA1530 - H00057654-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KIAA1530 fusion protein - ag21868 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human UVSSA - UVSSA-1243H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Uncharacterized protein KIAA1530(KIAA1530) - CSB-YP650553HU CSB-EP650553HU CSB-BP650553HU CSB-MP650553HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KIAA1530 - TP310690 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

UVSSA Peptide, Human - M34GP17221H from Creative Peptides Category Peptide Source Synthetic. Species Human

UVSSA Recombinant Protein Antigen - NBP2-48981PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

UVSSA Recombinant Protein Antigen - NBP2-55432PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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