TNS3

Gene Symbol TNS3
Entrez Gene 64759
Alt Symbol TEM6, TENS1
Species Human
Gene Type protein-coding
Description tensin 3
Other Description tensin-3|tensin-like SH2 domain containing 1|tensin-like SH2 domain-containing 1|tensin-like SH2 domain-containing protein 1|thyroid specific PTB domain protein|tumor endothelial marker 6
Swissprots Q8NAD0 Q6IPQ2 B2RNV1 Q96S48 Q96PE0 Q8IZW7 Q68CZ2
Accessions AAQ96841 CBX47573 EAW61011 EAW61012 EAW61013 EAW61014 EAW61015 Q68CZ2 AB062750 BAB60681 AB208995 BAD92232 AF378756 AAL11993 AF417489 AAN32667 AK001539 AK002151 AK023794 BAB14682 AK092864 BAC03993 AK310472 AL833845 CAD38705 BC071791 AAH71791 BC137133 AAI37134 BC137134 AAI37135 BX648770 BX649002 CR749644 CAH18438 XM_011515476 XP_011513778 XM_011515477 XP_011513779 XM_011515478 XP_011513780 XM_011515479 XP_011513781 XM_011515480 XP_011513782 XM_011515481 XP_011513783 XM_011515482 XP_011513784 XM_011515483 XP_011513785 XM_011515484 XP_011513786 NM_022748 NP_073585
Function May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, focal adhesion {ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:17643115}.
Tissue Specificity Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. {ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:16461921}.

Tns3 (C-2) - sc-376367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tns3 (C-2): sc-376367. Western blot analysis of Tns3 expression in Hs 67 whole cell lysate.

Tns3 (D-20) - sc-55152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tns3 (D-20): sc-55152. Western blot analysis of Tns3 expression in A549 (A), Hep G2 (B) and HUV-EC-C (C) whole cell lysates.

Tns3 (H-300) - sc-134908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tns3 (H-300): sc-134908. Western blot analysis of Tns3 expression in Hs67 whole cell lysate.

Tns3 (M-300) - sc-134909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Tns3 (N-15) - sc-55153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Tns3 (T-18) - sc-55155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Tensin 3 antibody - ab176433 from Abcam

Host Rabbit
Clonality Polyclonal
Total extracts from human Jurkat were immunoprecipitated  with IgG (1) or ab176433 at 1/100 dilution (2) followed by WB with the same Ab at RT for 2 h.

Anti-Tensin 3 antibody - ab178554 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human heart tissue labeling Tensin 3 with ab178554 at 1/50 dilution in the presence (right panel) or absence (left panel) of immunizing peptide.

Anti-TNS3 / Tensin 3 Antibody (Internal) - LS-C183411 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNS3 / Tensin 3 Antibody (aa175-224) - LS-C187359 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mouse Heart. Tns3 antibody dilution 1.0 ug/ml.

Anti-TNS3 / Tensin 3 Antibody (aa541-590) - LS-C199645 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human heart tissue, using TENS3 Antibody. The sample on the right was incubated with synthetic peptide.

TNS3 Antibody - NBP2-37952 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TNS3 Antibody [NBP2-37952] - Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & focal adhesion sites.

TNS3 Antibody - NBP2-37948 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TNS3 Antibody [NBP2-37948] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

Anti-Tensin 3 antibody produced in rabbit - SAB4200204 from Sigma-Aldrich

Prices $55.60, $322.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell lysates of HEK-293T overexpressing human Tensin 3 (lanes 1, 2) and HEK-293T non-transfected (lane 3) were separated on SDS-PAGE, blotted with Anti-Tensin 3 (<B>Cat. No. SAB4200204</B>), and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody: 1.5 μg/mL <BR/>2. Antibody: 1.5 μg/mL + Tensin 3 immunizing peptide (human, 25-42) <BR/>3. Antibody: 1.5 μg/mL

Anti-Tensin 3 (C-terminal) antibody produced in rabbit - SAB4200205 from Sigma-Aldrich

Prices $55.60, $322.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell lysates of HEK-293T overexpressing human Tensin 3 (lanes 1, 2) and HEK-293T non-transfected (lane 3) were separated on SDS-PAGE, blotted with Anti-Tensin 3 (C-terminal) (<B>Cat. No. SAB4200205</B>), and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody: 1.5 μg/mL <BR/>2. Antibody: 1.5 μg/mL + Tensin 3 immunizing peptide (human, 1282-1300) <BR/>3. Antibody: 1.5 μg/mL

Anti-TENS3 antibody produced in rabbit - SAB4502775 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TENS3, N-Terminal: <B>Cat. No. SAB4502775</B>: Immunohistochemistry analysis of paraffin-embedded human heart tissue using Anti-TENS3, N-Terminal antibody. Cells on the left were treated with the Anti-TENS3, N-Terminal antibody. Cells on the right (negative control) were treated with both Anti-TENS3, N-Terminal antibody and the synthesized immunogen peptide.

Monoclonal Anti-Tensin 3 antibody produced in mouse - SAB4200416 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone TN-17
<B>Immunofluorescence</B><BR/>PC3 cells were fixed and permeabilized with cold methanol followed by acetone. Fixed cells were stained with 2.5 μg/mL Mouse Anti-Tensin 3 Clone: TN-17 (<B>Cat. No. SAB4200416</B>). The antibody was developed using Goat Anti-Mouse IgG, Cy3<SUP>™</SUP> conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

Anti-Tensin 3 (N-terminal region) antibody produced in rabbit - SAB4200296 from Sigma-Aldrich

Prices $343.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell and tissue extracts were separated on SDS-PAGE, blotted with 1 μg/mL Anti-Tensin 3 (N-terminal region) (<B>Cat. No. SAB4200296</B>), and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. Additional lower bands observed in rat lung may represent tensin 3 degradation products.<BR/><B>Lanes</B><BR/>1. NIH3T3<BR/>2. NRK<BR/>3. Rat lung<BR/>4. HEK293-T overexpressing human tensin 3<BR/>5. HEK293-T non-transfected<BR/>6. HEK293-T overexpressing human tensin 3. Antibody + immunizing tensin 3 peptide

TNS3 Antibody (OAAF02499) - OAAF02499 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TENS3 antibody - 70R-31955 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

TNS3 antibody - 70R-20911 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

TNS3 antibody - 20053-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 20053-1-AP(TNS3 antibody) at dilution of 1:100

Anti-Tensin3 antibody - STJ95969 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

TNS3 antibody - 20053-1-AP from Proteintech Group

Prices $279.00
Sizes con: 45 μg/150μl
Host Rabbit
Clonality Polyclonal
mouse kidney tissue were subjected to SDS PAGE followed by western blot with 20053-1-AP(TNS3 antibody) at dilution of 1:100

TENS3, Polyclonal Antibody - MBS858665 from MyBioSource

Prices $215.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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