TNS3

Gene Symbol	TNS3
Entrez Gene	64759
Alt Symbol	TEM6, TENS1
Species	Human
Gene Type	protein-coding
Description	tensin 3
Other Description	tensin-3|tensin-like SH2 domain containing 1|tensin-like SH2 domain-containing 1|tensin-like SH2 domain-containing protein 1|thyroid specific PTB domain protein|tumor endothelial marker 6
Swissprots	Q8NAD0 Q6IPQ2 B2RNV1 Q96S48 Q96PE0 Q8IZW7 Q68CZ2
Accessions	AAQ96841 CBX47573 EAW61011 EAW61012 EAW61013 EAW61014 EAW61015 Q68CZ2 AB062750 BAB60681 AB208995 BAD92232 AF378756 AAL11993 AF417489 AAN32667 AK001539 AK002151 AK023794 BAB14682 AK092864 BAC03993 AK310472 AL833845 CAD38705 BC071791 AAH71791 BC137133 AAI37134 BC137134 AAI37135 BX648770 BX649002 CR749644 CAH18438 XM_011515476 XP_011513778 XM_011515477 XP_011513779 XM_011515478 XP_011513780 XM_011515479 XP_011513781 XM_011515480 XP_011513782 XM_011515481 XP_011513783 XM_011515482 XP_011513784 XM_011515483 XP_011513785 XM_011515484 XP_011513786 NM_022748 NP_073585
Function	May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity). {ECO:0000250}.
Subcellular Location	Cell junction, focal adhesion {ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:17643115}.
Tissue Specificity	Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. {ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:16461921}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TNS3 / Tensin 3 Antibody Blocking Peptide - LS-E24283 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNS3 fusion protein - ag19617 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TNS3 fusion protein - ag19563 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Tensin 3 (TNS3) - RPF819Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tensin 3 (TNS3) - RPF819Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Tensin-3(TNS3) ,partial - CSB-YP731561HU CSB-EP731561HU CSB-BP731561HU CSB-MP731561HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Tensin 3 Protein (Recombinant) - abx166762 from Abbexa Category Protein Source Human Species Human

TNS3 Protein - abx164530 from Abbexa Category Protein Species Human, Rat

Tensin 3, Recombinant Protein - MBS2030155 from MyBioSource Category Protein Prices $185.00, $380.00, $585.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Tensin-3 (TNS3), partial, Recombinant Protein - MBS1284031 from MyBioSource Category Protein Prices $305.00, $580.00, $950.00, $950.00, $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TNS3 Recombinant Protein Antigen - NBP2-37952PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TNS3 Protein - NBP2-37948PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Tensin 3 Blocking Peptide - CBP5323 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat

Recombinant Tensin 3 (TNS3) - RPU52287 from Biomatik Category Protein Prices $185.00, $378.00, $578.00, $688.80 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

TNS3 Recombinant Protein (OPCD07624) - OPCD07624 from Aviva Systems Biology Category Protein Source E.coli Species Human

TNS3 peptide - orb382180 from Biorbyt Category Peptide Species Human, Rat

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