PIM1

Gene Symbol PIM1
Entrez Gene 5292
Alt Symbol PIM
Species Human
Gene Type protein-coding
Description Pim-1 proto-oncogene, serine/threonine kinase
Other Description Oncogene PIM1|pim-1 kinase 44 kDa isoform|pim-1 oncogene (proviral integration site 1)|proto-oncogene serine/threonine-protein kinase pim-1|serine/threonine-protein kinase pim-1
Swissprots Q38RT9 Q96RG3 P11309 Q5T7H7
Accessions AAA60090 AAK70871 EAX03934 EAX03935 P11309 AK301158 BAG62748 AK301314 BAG62865 AK309347 BC020224 AAH20224 DA434260 DA481890 DA489942 DQ022562 AAY87461 M16750 AAA60089 M24779 AAA81553 M54915 AAA36447 NM_001243186 NP_001230115 NM_002648 NP_002639
Function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis.
Subcellular Location Isoform 2: Cytoplasm. Nucleus.
Tissue Specificity Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. {ECO:0000269|PubMed:16186805}.
Top Pathways Jak-STAT signaling pathway, Acute myeloid leukemia, MicroRNAs in cancer

HTScan ® Pim-1 Kinase Assay Kit - 7573 from Cell Signaling Technology

Category Assay Kit
Figure 1. Pim-1 kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 3 mM MgCl2, 3 mM MnCl2, 3 µM Na-orthovanadate, 1.2 mM DTT, ATP (variable), 2.5 µg/50 µl PEG20,000, Substrate: Histone H2B 5 µg/50 µl, recombinant Pim-1: 200 ng/50 µl.

Mouse/Human/Rat Phospho-PIM1 / Pim-1 (Tyr309) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1272 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.78-50 ng/ml

Mouse/Human/Rat PIM1 / Pim-1 ELISA Kit (Cell-Based ELISA) - LS-F2245 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.78-50 ng/ml

Human PIM1 / Pim-1 ELISA Kit (Sandwich ELISA) - LS-F7734 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.78 ng/ml
Range 0.78-50 ng/ml

Rabbit anti-PIM1 Antibody, Affinity Purified - PLA0088 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Pim-1 Oncogene (PIM1), Human, ELISA Kit - SEC578Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.25ng/mL
Range 0.78 -50ng/mL

Proto-oncogene serine/threonine-protein kinase pim-1 (PIM1), Human, ELISA Kit - CSB-E11825h from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml -20 ng/ml

Pim-1 Oncogene (PIM1), Human, CLIA Kit - SCC578Hu from ARP American Research Products

Category CLIA Kit
Prices $840.00
Sizes 96 t
Sensitivity 0.29ng/mL
Range 0.78-50ng/mL

Pim 1 Oncogene, ELISA Kit - MBS753981 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS747780 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

pim-1 oncogene, ELISA Kit - MBS701210 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml -20 ng/ml

Pim-1 Oncogene, ELISA Kit - MBS755543 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Pim-1 Oncogene, ELISA Kit - MBS747104 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Colorimetric Cell-Based ELISA Kit - CB5558 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Pim-1 (Phospho-Tyr309) Colorimetric Cell-Based ELISA Kit - CBP1272 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Pim-1 Oncogene, ELISA Kit - MBS754307 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS751785 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS747435 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS751033 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS747455 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS748511 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pim-1 Oncogene, ELISA Kit - MBS744423 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Pim-1 Oncogene, ELISA Kit - MBS744956 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Pim-1 Oncogene (PIM1), ELISA Kit - MBS2019381 from MyBioSource

Category ELISA Kit
Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00
Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 0.25ng/mL.
Range 0.781-50ng/mL

ELISA Kit for Pim-1 Oncogene (PIM1) - SEC578Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.25ng/mL.
Range 0.781-50ng/mL The standard curve concentrations used for the ELISA’s were 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL, 0.781ng/mL
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