| Gene Symbol |
PIM1
|
| Entrez Gene |
5292
|
| Alt Symbol |
PIM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Pim-1 proto-oncogene, serine/threonine kinase
|
| Other Description |
Oncogene PIM1|pim-1 kinase 44 kDa isoform|pim-1 oncogene (proviral integration site 1)|proto-oncogene serine/threonine-protein kinase pim-1|serine/threonine-protein kinase pim-1
|
| Swissprots |
Q38RT9 Q96RG3 P11309 Q5T7H7
|
| Accessions |
AAA60090 AAK70871 EAX03934 EAX03935 P11309 AK301158 BAG62748 AK301314 BAG62865 AK309347 BC020224 AAH20224 DA434260 DA481890 DA489942 DQ022562 AAY87461 M16750 AAA60089 M24779 AAA81553 M54915 AAA36447 NM_001243186 NP_001230115 NM_002648 NP_002639
|
| Function |
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis.
|
| Subcellular Location |
Isoform 2: Cytoplasm. Nucleus.
|
| Tissue Specificity |
Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. {ECO:0000269|PubMed:16186805}.
|
| Top Pathways |
Jak-STAT signaling pathway, Acute myeloid leukemia, MicroRNAs in cancer
|
![Western Blot: PIM1 Overexpression Lysate (Adult Normal) [NBL1-14426] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PIM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7010_PIM1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14426-img0002.jpg)