Gene Symbol | PDE1B |
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Entrez Gene | 5153 |
Alt Symbol | PDE1B1, PDES1B |
Species | Human |
Gene Type | protein-coding |
Description | phosphodiesterase 1B, calmodulin-dependent |
Other Description | 63 kDa Cam-PDE|calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B|calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase|calmodulin-stimulated phosphodiesterase PDE1B1|cam-PDE 1B|presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B |
Swissprots | Q92825 Q96KP3 Q01064 |
Accessions | AAC51871 EAW96788 EAW96789 EAW96790 EAW96791 Q01064 AB209200 BAD92437 AJ401609 CAC82207 AK126899 BAG54390 AK296422 BAG59084 AK302899 BAG64072 AK302931 BAG64092 BC032226 AAH32226 BP342896 BX538092 CAD98011 DA254686 DC298452 DC392024 DQ891673 ABM82599 DQ894859 ABM85785 EU668337 ACF94490 M94539 AAA58405 U40584 AAB50018 U56976 AAC50769 U86078 AAC51872 XM_006719451 XP_006719514 XM_011538456 XP_011536758 NM_000924 NP_000915 NM_001165975 NP_001159447 NM_001288768 NP_001275697 NM_001288769 NP_001275698 |
Function | Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269|PubMed:15260978}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Calcium signaling pathway, Morphine addiction, Purine metabolism |
PDE1B CRISPR/Cas9 KO Plasmid (h) - sc-406446 from Santa Cruz Biotechnology
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PDE1B HDR Plasmid (h) - sc-406446-HDR from Santa Cruz Biotechnology
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PDE1B Double Nickase Plasmid (h) - sc-406446-NIC from Santa Cruz Biotechnology
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PDE1B Double Nickase Plasmid (h2) - sc-406446-NIC-2 from Santa Cruz Biotechnology
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PDE1B CRISPR Activation Plasmid (h) - sc-406446-ACT from Santa Cruz Biotechnology
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PDE1B CRISPR Activation Plasmid (h2) - sc-406446-ACT-2 from Santa Cruz Biotechnology
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PDE1B Lentiviral Activation Particles (h) - sc-406446-LAC from Santa Cruz Biotechnology
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PDE1B Lentiviral Activation Particles (h2) - sc-406446-LAC-2 from Santa Cruz Biotechnology
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PDE1B siRNA (h) - sc-60088 from Santa Cruz Biotechnology
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PDE1B shRNA Plasmid (h) - sc-60088-SH from Santa Cruz Biotechnology
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PDE1B shRNA (h) Lentiviral Particles - sc-60088-V from Santa Cruz Biotechnology
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PDE1B RNAi - H00005153-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16531 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09706 from Sigma-Aldrich
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PDE1B siRNA (Human) - CRH3433 from Cohesion Biosciences
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shRNA set against Human PDE1B (NM_000924.3) - SHH372368 from Creative biogene
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Human PDE1B siRNA - orb263935 from Biorbyt
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PDE1B shRNA Plasmid (Human) - CHH3433 from Cohesion Biosciences
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PDE1B miRNA 3'UTR clone - MiUTR3H-01728 from Creative biogene
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PDE1B miRNA 3'UTR clone - MiUTR3H-01729 from Creative biogene
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