| Gene Symbol |
RIN2
|
| Entrez Gene |
54453
|
| Alt Symbol |
MACS, RASSF4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras and Rab interactor 2
|
| Other Description |
RAB5 interacting protein 2|RAS association (RalGDS/AF-6) domain containing protein JC265|RAS association domain family 4|RAS inhibitor JC265|RAS interaction/interference protein 2|ras and Rab interactor 2
|
| Swissprots |
Q9H071 Q00425 Q5TFT8 Q9BQL3 Q8WYP3
|
| Accessions |
EAX10216 EAX10217 Q8WYP3 AB060339 BAB84317 AI695804 AK026753 AK094884 BAG52947 AL136924 CAB66858 BC034698 BC090059 BC128065 AAI28066 BM973182 HG511229 HG511230 HG511231 M37190 AAA36553 XM_005260731 XP_005260788 XM_005260732 XP_005260789 XM_005260733 XP_005260790 XM_006723574 XP_006723637 XM_006723575 XP_006723638 XM_006723577 XP_006723640 XM_011529255 XP_011527557 XM_011529256 XP_011527558 XM_011529257 XP_011527559 XM_011529258 XP_011527560 XM_011529259 XP_011527561 XM_011529260 XP_011527562 NM_001242581 NP_001229510 NM_018993 NP_061866
|
| Function |
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. {ECO:0000269|PubMed:11733506}.
|