Gene Symbol | RIN2 |
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Entrez Gene | 54453 |
Alt Symbol | MACS, RASSF4 |
Species | Human |
Gene Type | protein-coding |
Description | Ras and Rab interactor 2 |
Other Description | RAB5 interacting protein 2|RAS association (RalGDS/AF-6) domain containing protein JC265|RAS association domain family 4|RAS inhibitor JC265|RAS interaction/interference protein 2|ras and Rab interactor 2 |
Swissprots | Q9H071 Q00425 Q5TFT8 Q9BQL3 Q8WYP3 |
Accessions | EAX10216 EAX10217 Q8WYP3 AB060339 BAB84317 AI695804 AK026753 AK094884 BAG52947 AL136924 CAB66858 BC034698 BC090059 BC128065 AAI28066 BM973182 HG511229 HG511230 HG511231 M37190 AAA36553 XM_005260731 XP_005260788 XM_005260732 XP_005260789 XM_005260733 XP_005260790 XM_006723574 XP_006723637 XM_006723575 XP_006723638 XM_006723577 XP_006723640 XM_011529255 XP_011527557 XM_011529256 XP_011527558 XM_011529257 XP_011527559 XM_011529258 XP_011527560 XM_011529259 XP_011527561 XM_011529260 XP_011527562 NM_001242581 NP_001229510 NM_018993 NP_061866 |
Function | Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Tissue Specificity | Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. {ECO:0000269|PubMed:11733506}. |
RIN2 CRISPR/Cas9 KO Plasmid (h) - sc-417092 from Santa Cruz Biotechnology
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RIN2 HDR Plasmid (h) - sc-417092-HDR from Santa Cruz Biotechnology
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RIN2 Double Nickase Plasmid (h) - sc-417092-NIC from Santa Cruz Biotechnology
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RIN2 Double Nickase Plasmid (h2) - sc-417092-NIC-2 from Santa Cruz Biotechnology
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RIN2 CRISPR Activation Plasmid (h) - sc-417092-ACT from Santa Cruz Biotechnology
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RIN2 CRISPR Activation Plasmid (h2) - sc-417092-ACT-2 from Santa Cruz Biotechnology
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RIN2 Lentiviral Activation Particles (h) - sc-417092-LAC from Santa Cruz Biotechnology
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RIN2 Lentiviral Activation Particles (h2) - sc-417092-LAC-2 from Santa Cruz Biotechnology
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RIN2 siRNA (h) - sc-76407 from Santa Cruz Biotechnology
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RIN2 shRNA Plasmid (h) - sc-76407-SH from Santa Cruz Biotechnology
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RIN2 shRNA (h) Lentiviral Particles - sc-76407-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU019621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18291 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09749 from Sigma-Aldrich
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RIN2 siRNA (Human) - CRJ0062 from Cohesion Biosciences
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RIN2 RNAi - H00054453-R01 from Novus Biologicals
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RIN2 - MBS829683 from MyBioSource
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shRNA set against Human RIN2 (NM_018993.3) - SHH395892 from Creative biogene
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Human RIN2 siRNA - orb270563 from Biorbyt
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RIN2 shRNA Plasmid (Human) - CHJ0062 from Cohesion Biosciences
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RIN2 miRNA 3'UTR clone - MiUTR3H-11094 from Creative biogene
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