NDEL1

Gene Symbol	NDEL1
Entrez Gene	81565
Alt Symbol	EOPA, MITAP1, NDE1L1, NDE2, NUDEL
Species	Human
Gene Type	protein-coding
Description	nudE neurodevelopment protein 1-like 1
Other Description	endooligopeptidase A|mitosin-associated protein 1|mitosin-associated protein MITAP1|nuclear distribution protein nudE-like 1|nudE nuclear distribution E homolog-like 1|nudE nuclear distribution gene E homolog-like 1|protein Nudel
Swissprots	B3KP93 Q86T80 J3QT32 D3DTS0 Q8TAR7 Q9UH50 Q9GZM8
Accessions	CAD34820 EAW90051 EAW90052 Q9GZM8 AA232258 AA425741 AF038203 AF182078 AAG43425 AF217798 AAF24516 AI742227 AK056014 BAG51605 AK095179 AK123802 AK128514 AK299559 BAG61503 AL832648 CAD89957 AW795298 AY004871 AAF97497 BC026101 AAH26101 BP201698 CX166766 DA256375 DB176966 DN993952 HQ447858 ADQ32342 R94775 XM_006721580 XP_006721643 XM_011524012 XP_011522314 XM_011524013 XP_011522315 NM_001025579 NP_001020750 NM_030808 NP_110435
Function	Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:16005531}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NDEL1 (D-5) - sc-365094 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NDEL1 (H-65) - sc-134517 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NDEL1 (C-20) - sc-48063 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

p-NDEL1 (Ser 242) - sc-130207 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-Nudel (phospho T245) antibody - ab60006 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Nudel antibody - ab25959 from Abcam Prices $390.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Nudel antibody - ab93339 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Nudel antibody [EPR5068] - ab124895 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR5068

Anti-NUDEL / NDEL1 Antibody - LS-C91122 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-NUDEL / NDEL1 Antibody - LS-C341864 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUDEL / NDEL1 Antibody (aa273-286) - LS-C87402 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-NUDEL / NDEL1 Antibody - LS-C334282 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NUDEL / NDEL1 Antibody (clone 5C2) - LS-C173188 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5C2

Anti-NUDEL / NDEL1 Antibody (clone 1G7) - LS-C173157 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1G7

Anti-NUDEL / NDEL1 Antibody (clone 3B9) - LS-C173131 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3B9

Anti-NUDEL / NDEL1 Antibody (clone 1C7) - LS-C173041 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1C7

Anti-NUDEL / NDEL1 Antibody (clone 4E5) - LS-C173209 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4E5

Anti-NUDEL / NDEL1 Antibody (clone 1G10) - LS-C173040 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1G10

Anti-NUDEL / NDEL1 Antibody (clone 5E11) - LS-C173210 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5E11

Nudel Antibody (5E11) - NBP2-01086 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5E11

Nudel Antibody - NBP1-76677 from Novus Biologicals Prices $299.00, $329.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

Nudel Antibody - NBP1-28801 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

Nudel Antibody - H00081565-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

NUDEL Polyclonal Antibody - bs-4141R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

NDEL1(Ser231) Polyclonal Antibody - bs-5522R from Bioss Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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