NDEL1

Gene Symbol	NDEL1
Entrez Gene	81565
Alt Symbol	EOPA, MITAP1, NDE1L1, NDE2, NUDEL
Species	Human
Gene Type	protein-coding
Description	nudE neurodevelopment protein 1-like 1
Other Description	endooligopeptidase A|mitosin-associated protein 1|mitosin-associated protein MITAP1|nuclear distribution protein nudE-like 1|nudE nuclear distribution E homolog-like 1|nudE nuclear distribution gene E homolog-like 1|protein Nudel
Swissprots	B3KP93 Q86T80 J3QT32 D3DTS0 Q8TAR7 Q9UH50 Q9GZM8
Accessions	CAD34820 EAW90051 EAW90052 Q9GZM8 AA232258 AA425741 AF038203 AF182078 AAG43425 AF217798 AAF24516 AI742227 AK056014 BAG51605 AK095179 AK123802 AK128514 AK299559 BAG61503 AL832648 CAD89957 AW795298 AY004871 AAF97497 BC026101 AAH26101 BP201698 CX166766 DA256375 DB176966 DN993952 HQ447858 ADQ32342 R94775 XM_006721580 XP_006721643 XM_011524012 XP_011522314 XM_011524013 XP_011522315 NM_001025579 NP_001020750 NM_030808 NP_110435
Function	Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
Subcellular Location	Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.
Tissue Specificity	Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:16005531}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nudel full length protein - ab183232 from Abcam Category Protein Source E. coli Species Human

Human Nudel peptide - ab39840 from Abcam Category Peptide Species Human

NUDEL / NDEL1 Antibody Blocking Peptide - LS-E26985 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Nudel Recombinant Protein - H00081565-P01 from Novus Biologicals Category Protein Species Human

Nudel Blocking Peptide - NBP1-76677PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Nudel Peptide - P1362 from Novus Biologicals Category Peptide Species Human

Nudel Peptide - P1361 from Novus Biologicals Category Peptide Species Human

Phospho-NudelS242-Antibody-Blocking-peptide - BP3180a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-NudelS231-Antibody-Blocking-peptide - BP3179a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

NDEL1-Antibody-Center-Blocking-Peptide - BP8736c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Nudel blocking peptide - GTX88469-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Goat anti NDEL1 antibody Immunizing peptide - orb17229 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

NDEL1 protein (His tag) - 80R-3923 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

Nudel Peptide - AC21-1810-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NDEL (1-328, His-tag) - AR51610PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

NDEL (1-328, His-tag) - AR51610PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

NDEL - H00081565-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

NDEL - H00081565-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NDEL Control Peptide - AP30617CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NDEL1 Peptide - 46-929P from ProSci Category Peptide Species Human

Nudel Peptide - 3009P from ProSci Category Peptide Species Human

NDEL1 fusion protein - ag10975 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NDEL1 fusion protein - ag11197 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Nuclear distribution protein nudE-like 1(NDEL1) - CSB-YP872414HU CSB-EP872414HU CSB-BP872414HU CSB-MP872414HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NDEL1, 1-328aa, Human, His tag, E.coli - ATGP2790 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

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