| Gene Symbol |
NDEL1
|
| Entrez Gene |
81565
|
| Alt Symbol |
EOPA, MITAP1, NDE1L1, NDE2, NUDEL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudE neurodevelopment protein 1-like 1
|
| Other Description |
endooligopeptidase A|mitosin-associated protein 1|mitosin-associated protein MITAP1|nuclear distribution protein nudE-like 1|nudE nuclear distribution E homolog-like 1|nudE nuclear distribution gene E homolog-like 1|protein Nudel
|
| Swissprots |
B3KP93 Q86T80 J3QT32 D3DTS0 Q8TAR7 Q9UH50 Q9GZM8
|
| Accessions |
CAD34820 EAW90051 EAW90052 Q9GZM8 AA232258 AA425741 AF038203 AF182078 AAG43425 AF217798 AAF24516 AI742227 AK056014 BAG51605 AK095179 AK123802 AK128514 AK299559 BAG61503 AL832648 CAD89957 AW795298 AY004871 AAF97497 BC026101 AAH26101 BP201698 CX166766 DA256375 DB176966 DN993952 HQ447858 ADQ32342 R94775 XM_006721580 XP_006721643 XM_011524012 XP_011522314 XM_011524013 XP_011522315 NM_001025579 NP_001020750 NM_030808 NP_110435
|
| Function |
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:16005531}.
|