Gene Symbol | SGCA |
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Entrez Gene | 6442 |
Alt Symbol | 50-DAG, A2, ADL, DAG2, DMDA2, LGMD2D, SCARMD1, adhalin |
Species | Human |
Gene Type | protein-coding |
Description | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
Other Description | 50 kDa dystrophin-associated glycoprotein|50DAG|50kD DAG|alpha-SG|alpha-sarcoglycan|dystroglycan-2 |
Swissprots | Q13710 Q13712 A8K3K7 A6NEB8 Q16586 |
Accessions | CCQ42962 EAW94634 EAW94635 Q16586 AK290622 BAF83311 AK293614 BAH11547 AK300710 BAH13330 BC025702 AAH25702 DQ893777 ABM84703 F25770 L34355 AAA35510 L35853 AAA50461 L46810 AAC37583 U08895 AAA81637 XM_011525120 XP_011523422 XM_011525121 XP_011523423 XM_011525122 XP_011523424 XM_011525123 XP_011523425 XM_011525124 XP_011523426 XR_934517 NM_000023 NP_000014 NM_001135697 NP_001129169 |
Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Subcellular Location | Cell membrane, sarcolemma {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
Tissue Specificity | Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Human alpha Sarcoglycan full length protein - ab132339 from Abcam
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Human alpha Sarcoglycan protein fragment - ab114733 from Abcam
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SGCA / DAG2 Antibody Blocking Peptide - LS-E4836 from LifeSpan Bioscience
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Recombinant Human alpha-Sarcoglycan Protein - H00006442-P01 from Novus Biologicals
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Recombinant Human alpha-Sarcoglycan Protein - H00006442-Q01 from Novus Biologicals
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SGCA-Antibody-Center-Blocking-Peptide - BP17217c from Abgent, a WuXi AppTec company
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SGCA peptide - orb217925 from Biorbyt
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Alpha-sarcoglycan Blocking Peptide - abx063256 from Abbexa
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SGCA (Alpha-sarcoglycan) - H00006442-P01-10 from Acris Antibodies
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SGCA (Alpha-sarcoglycan) - H00006442-P01-25 from Acris Antibodies
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SGCA (Alpha-sarcoglycan) - H00006442-Q01-10 from Acris Antibodies
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SGCA (Alpha-sarcoglycan) - H00006442-Q01-25 from Acris Antibodies
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SGCA fusion protein - ag3924 from Proteintech Group
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Recombinant Human SGCA - SGCA-27337TH from Creative Biomart
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Alpha-sarcoglycan Blocking Peptide - CBP2062 from Cohesion Biosciences
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Sarcoglycan-α Peptide - BS5920P from Bioworld Technology
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Recombinant Human Alpha-sarcoglycan(SGCA) - CSB-YP623086HU CSB-EP623086HU CSB-BP623086HU CSB-MP623086HU from Cusabio
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Alpha-sarcoglycan(SGCA) - MBS1427227 from MyBioSource
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SGCA (Alpha-sarcoglycan) (transcript variant 1) - TP306577 from Acris Antibodies
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SGCA fusion protein - Ag25143 from Proteintech Group
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alpha-Sarcoglycan Recombinant Protein Antigen - NBP1-90306PEP from Novus Biologicals
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SGCA Peptide, Human - M34GP14127H from Creative Peptides
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SGCA fusion protein - Ag25520 from Proteintech Group
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Sarcoglycan Alpha (SGCa), Recombinant Protein - MBS2086819 from MyBioSource
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