EIF4A3

Gene Symbol	EIF4A3
Entrez Gene	9775
Alt Symbol	DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4A3
Other Description	ATP-dependent RNA helicase DDX48|ATP-dependent RNA helicase eIF4A-3|DEAD (Asp-Glu-Ala-Asp) box polypeptide 48|DEAD box protein 48|NMP 265|eIF-4A-III|eIF4A-III|eukaryotic initiation factor 4A-III|eukaryotic initiation factor 4A-like NUK-34|eukaryotic translation initiation factor 4A|hNMP 265|nuclear matrix protein 265
Swissprots	P38919 Q15033 Q6IBQ2 Q96A18
Accessions	EAW89584 EAW89585 P38919 AK290608 BAF83297 BC003662 AAH03662 BC004386 AAH04386 BC011151 AAH11151 CA428254 CR456750 CAG33031 CR749455 D21853 BAA04879 DA667983 X79538 CAA56074 XM_011525522 XP_011523824 NM_014740 NP_055555
Function	ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by
Subcellular Location	Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10623621}.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

eIF4AIII (B-2) - sc-365549 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

eIF4AIII (3F1) - sc-33632 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

eIF4AIII (T-19) - sc-51487 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

eIF4AIII (H-50) - sc-67369 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-eIF4A3 antibody [2256C1] - ab50741 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2256C1

Anti-eIF4A3 antibody [EPR14302(B)] - ab180519 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR14302(B)

Anti-eIF4A3 antibody - C-terminal - ab139043 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325, PE) - LS-C213757 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa136-185) - LS-C30983 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325, FITC) - LS-C213755 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325) - LS-C159519 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325) - LS-C321076 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa51-100) - LS-C117097 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (clone 2256C1) - LS-C342464 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2256C1

Anti-EIF4A3 Antibody - LS-C333246 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa1-50) - LS-C289686 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa125-175) - LS-C289688 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (clone 2256C1) - LS-C64616 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2256C1

Anti-EIF4A3 Antibody - LS-C125440 from LifeSpan Bioscience Prices $425.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (clone 2256C1) - LS-C184419 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2256C1

Anti-EIF4A3 Antibody (aa297-325, AP) - LS-C213750 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325, Biotin) - LS-C213754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325, APC) - LS-C213753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EIF4A3 Antibody (aa297-325, Azide-free, HRP) - LS-C213756 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

EIF4A3 Antibody - NBP1-85268 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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