EIF4A3

Gene Symbol	EIF4A3
Entrez Gene	9775
Alt Symbol	DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4A3
Other Description	ATP-dependent RNA helicase DDX48|ATP-dependent RNA helicase eIF4A-3|DEAD (Asp-Glu-Ala-Asp) box polypeptide 48|DEAD box protein 48|NMP 265|eIF-4A-III|eIF4A-III|eukaryotic initiation factor 4A-III|eukaryotic initiation factor 4A-like NUK-34|eukaryotic translation initiation factor 4A|hNMP 265|nuclear matrix protein 265
Swissprots	P38919 Q15033 Q6IBQ2 Q96A18
Accessions	EAW89584 EAW89585 P38919 AK290608 BAF83297 BC003662 AAH03662 BC004386 AAH04386 BC011151 AAH11151 CA428254 CR456750 CAG33031 CR749455 D21853 BAA04879 DA667983 X79538 CAA56074 XM_011525522 XP_011523824 NM_014740 NP_055555
Function	ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by
Subcellular Location	Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:10623621}.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human eIF4A3 full length protein - ab123151 from Abcam Category Protein Source E. coli Species Human

Human eIF4A3 peptide - ab32484 from Abcam Category Peptide

Human eIF4A3 protein fragment - ab91993 from Abcam Category Protein Source E. coli Species Human

EIF4A3 Antibody Blocking Peptide - LS-E13046 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF4A3 Antibody Blocking Peptide - LS-E6556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EIF4A3 Protein - H00009775-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

EIF4A3 Recombinant Protein - H00009775-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human EIF4A3 Protein - NBP1-78833 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

EIF4A3-Antibody-C-term-Blocking-Peptide - BP19330b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human EIF4A3 protein - orb168285 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

DDX48 Blocking Peptide - 33R-7488 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EIF4A3 Blocking Peptide - 33R-7927 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EIF4A3 protein (His tag) - 80R-2076 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

EIF4A3 (1-411, His-tag) - AR50159PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

EIF4A3 (1-411, His-tag) - AR50159PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

EIF4A3 - H00009775-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EIF4A3 - H00009775-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EIF4A3 - H00009775-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EIF4A3 - H00009775-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Eukaryotic Translation Initiation Factor 4A3, Human Recombinant - 228-12827-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Eukaryotic Translation Initiation Factor 4A3 - 228-12827-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Eukaryotic Translation Initiation Factor 4A3 - 228-12827-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

EIF4A3, 1-411aa, Human, His tag, E.coli - 01-P1334 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EIF4A3 fusion protein - Ag11701 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EIF4A3 fusion protein - Ag11130 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Search more