KAT2B

Gene Symbol	KAT2B
Entrez Gene	8850
Alt Symbol	CAF, P/CAF, PCAF
Species	Human
Gene Type	protein-coding
Description	K(lysine) acetyltransferase 2B
Other Description	CREBBP-associated factor|histone acetylase PCAF|histone acetyltransferase KAT2B|histone acetyltransferase PCAF|lysine acetyltransferase 2B|p300/CBP-associated factor
Swissprots	Q92831 Q6NSK1
Accessions	CAL00151 EAW64305 EAW64306 Q92831 AL832173 BC060823 AAH60823 BC070075 AAH70075 U57317 AAC50890 XM_005265528 XP_005265585 XM_011534206 XP_011532508 XR_245162 NM_003884 NP_003875
Function	Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9707565}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269|PubMed:8684459}.
Top Pathways	Notch signaling pathway, HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KAT2B / PCAF protein fragment - ab62629 from Abcam Category Protein Prices $306.00 Sizes 100 µg Source E. coli Species Human

Human KAT2B / PCAF full length protein - ab82074 from Abcam Category Protein Source Baculovirus Species Human

Human KAT2B / PCAF protein fragment - ab176938 from Abcam Category Protein Source E. coli Species Human

Human KAT2B / PCAF protein fragment - ab196399 from Abcam Category Protein Source E. coli Species Human

KAT2B / PCAF protein fragment - ab56275 from Abcam Category Protein Source E. coli

KAT2B / PCAF Antibody Blocking Peptide - LS-E1409 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KAT2B / PCAF Antibody Blocking Peptide - LS-E1408 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KAT2B / PCAF Antibody Blocking Peptide - LS-E11377 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KAT2B / PCAF Antibody Blocking Peptide - LS-E21174 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PCAF Protein - H00008850-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PCAF Protein - H00008850-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PCAF Protein - NBP1-99570 from Novus Biologicals Category Protein Prices $265.00 Sizes 100 µg Source E. coli Species Human

PCAF Peptide - NBP1-67656PEP from Novus Biologicals Category Peptide

PCAF-Antibody-C-term-Blocking-peptide - BP12075b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCAF-Antibody-N-term-Blocking-peptide - BP12074a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PCAF Blocking Peptide - abx063526 from Abbexa Category Peptide Species Human, Mouse, Bovine, Dog, Pig

PCAF / KAT2B - H00008850-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PCAF / KAT2B - H00008850-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PCAF / KAT2B - H00008850-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PCAF / KAT2B - H00008850-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PCAF / KAT2B - H00008850-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KAT2B fusion protein - Ag5028 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

KAT2B fusion protein - ag5787 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant PCAF (715-829) protein - 31370 from ActiveMotif Category Protein Prices $395.00, $3,500.00 Sizes 100 µg, 1 mg Source E. coli Species Human

Recombinant Human K (lysine) Acetyltransferase 2B - KAT2B-1654H from Creative Biomart Category Protein Source E. coli Species Human

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