| Gene Symbol | KAT2B |
|---|---|
| Entrez Gene | 8850 |
| Alt Symbol | CAF, P/CAF, PCAF |
| Species | Human |
| Gene Type | protein-coding |
| Description | K(lysine) acetyltransferase 2B |
| Other Description | CREBBP-associated factor|histone acetylase PCAF|histone acetyltransferase KAT2B|histone acetyltransferase PCAF|lysine acetyltransferase 2B|p300/CBP-associated factor |
| Swissprots | Q92831 Q6NSK1 |
| Accessions | CAL00151 EAW64305 EAW64306 Q92831 AL832173 BC060823 AAH60823 BC070075 AAH70075 U57317 AAC50890 XM_005265528 XP_005265585 XM_011534206 XP_011532508 XR_245162 NM_003884 NP_003875 |
| Function | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9707565}. |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269|PubMed:8684459}. |
| Top Pathways | Notch signaling pathway, HTLV-I infection, Viral carcinogenesis |
PCAF CRISPR/Cas9 KO Plasmid (h) - sc-400753 from Santa Cruz Biotechnology
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PCAF HDR Plasmid (h) - sc-400753-HDR from Santa Cruz Biotechnology
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PCAF Double Nickase Plasmid (h) - sc-400753-NIC from Santa Cruz Biotechnology
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PCAF Double Nickase Plasmid (h2) - sc-400753-NIC-2 from Santa Cruz Biotechnology
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PCAF CRISPR Activation Plasmid (h) - sc-400753-ACT from Santa Cruz Biotechnology
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PCAF CRISPR Activation Plasmid (h2) - sc-400753-ACT-2 from Santa Cruz Biotechnology
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PCAF Lentiviral Activation Particles (h) - sc-400753-LAC from Santa Cruz Biotechnology
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PCAF Lentiviral Activation Particles (h2) - sc-400753-LAC-2 from Santa Cruz Biotechnology
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PCAF siRNA (h) - sc-36198 from Santa Cruz Biotechnology
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PCAF shRNA Plasmid (h) - sc-36198-SH from Santa Cruz Biotechnology
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PCAF shRNA (h) Lentiviral Particles - sc-36198-V from Santa Cruz Biotechnology
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PCAF RNAi - H00008850-R01V from Novus Biologicals
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PCAF RNAi - H00008850-R01 from Novus Biologicals
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MISSION® esiRNA - EHU020571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1348 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10896 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1348 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10896 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10588 from Sigma-Aldrich
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KAT2B siRNA (Human) - CRH5843 from Cohesion Biosciences
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KAT2B, siRNA - MBS8221451 from MyBioSource
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shRNA set against Human KAT2B (NM_003884.4) - SHH322427 from Creative biogene
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KAT2B shRNA Plasmid (Human) - CHH5843 from Cohesion Biosciences
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KAT2B miRNA 3'UTR clone - MiUTR1H-07552 from Creative biogene
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