KAT2B

Gene Symbol	KAT2B
Entrez Gene	8850
Alt Symbol	CAF, P/CAF, PCAF
Species	Human
Gene Type	protein-coding
Description	K(lysine) acetyltransferase 2B
Other Description	CREBBP-associated factor|histone acetylase PCAF|histone acetyltransferase KAT2B|histone acetyltransferase PCAF|lysine acetyltransferase 2B|p300/CBP-associated factor
Swissprots	Q92831 Q6NSK1
Accessions	CAL00151 EAW64305 EAW64306 Q92831 AL832173 BC060823 AAH60823 BC070075 AAH70075 U57317 AAC50890 XM_005265528 XP_005265585 XM_011534206 XP_011532508 XR_245162 NM_003884 NP_003875
Function	Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9707565}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269|PubMed:8684459}.
Top Pathways	Notch signaling pathway, HTLV-I infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PCAF (C14G9) Rabbit mAb - 3378 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C14G9

PCAF (E-8) - sc-13124 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PCAF (C-16) - sc-6300 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PCAF (D-20) - sc-6301 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PCAF (H-369) - sc-8999 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF antibody - ab96510 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF antibody - ab56535 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-KAT2B / PCAF antibody [EPR2670(N)] - ab176316 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2670(N)

Anti-KAT2B / PCAF Antibody (Phe820) - LS-C176294 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (N-Terminus) - LS-C26005 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-KAT2B / PCAF Antibody (aa817-832) - LS-C26003 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (C-Terminus) - LS-C26004 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-KAT2B / PCAF Antibody (N-Terminus) - LS-C26006 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-KAT2B / PCAF Antibody (clone 1C11) - LS-C139489 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C11

Anti-KAT2B / PCAF Antibody (clone 4H8) - LS-C139502 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4H8

Anti-KAT2B / PCAF Antibody (clone 1C9) - LS-C139503 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C9

Anti-KAT2B / PCAF Antibody (aa190-239) - LS-C31431 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (clone 4D11) - LS-C139504 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4D11

Anti-KAT2B / PCAF Antibody (clone 4C10) - LS-C139505 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4C10

Anti-KAT2B / PCAF Antibody (aa782-832) - LS-C288456 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody - LS-C347585 from LifeSpan Bioscience Prices $425.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (N-Terminus) - LS-C347650 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (clone 1E3) - LS-C139387 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E3

Anti-KAT2B / PCAF Antibody (aa686-735) - LS-C82002 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KAT2B / PCAF Antibody (C-Terminus) - LS-C347652 from LifeSpan Bioscience Prices $405.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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