BAIAP2

Gene Symbol	BAIAP2
Entrez Gene	10458
Alt Symbol	BAP2, FLAF3, IRSP53
Species	Human
Gene Type	protein-coding
Description	BAI1-associated protein 2
Other Description	IRS-58|IRSp53/58|brain-specific angiogenesis inhibitor 1-associated protein 2|fas ligand-associated factor 3|insulin receptor substrate p53/p58|insulin receptor substrate protein of 53 kDa
Swissprots	Q53HB1 O43858 Q9UQB8 Q9UBR3 Q86WC1 Q96CR7 Q8N5C0 Q9UQ43
Accessions	BAC57945 BAC57946 BAC57947 BAC57948 EAW89625 EAW89626 EAW89627 EAW89628 Q9UQB8 AB015019 BAA36586 AB015020 BAA36587 AB017119 BAA74773 AB017120 BAA74774 AK023688 AK056888 BAG51821 AK127291 AK222670 BAD96390 AK225612 AK297644 BAG60012 AK298629 BAG60805 AK301436 BAG62963 BC002495 BC014020 AAH14020 BC032559 AAH32559 CB153324 DQ893456 ABM84382 DQ896329 ABM87328 U70669 AAB93497 XM_005256943 XP_005257000 XM_005256944 XP_005257001 XM_005256945 XP_005257002 XM_005256948 XP_005257005 XM_006721635 XP_006721698 XM_006721636 XP_006721699 XM_006721637 XP_006721700 XM_011524193 XP_011522495 XM_011524194 XP_011522496 XM_011524195 XP_011522497 XM_011524196 XP_011522498 XM_011524197 XP_011522499 NM_001144888 NP_001138360 NM_006340 NP_006331 NM_017450 NP_059344 NM_017451 NP_059345
Function	Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Tissue Specificity	Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. {ECO:0000269|PubMed:10332026, ECO:0000269|PubMed:10343108, ECO:0000269|PubMed:11157984}.
Top Pathways	Adherens junction, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IRSp53 (46) - sc-136470 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IRSp53 (H-99) - sc-134810 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IRSp53 (C-16) - sc-50008 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IRSp53 (W-20) - sc-50011 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-BAI1 associated protein 2 isoform 3 antibody - ab791 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BAIAP2 antibody - ab126057 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 antibody - ab176896 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BAIAP2 antibody - ab37542 from Abcam Prices $380.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 antibody - ab105221 from Abcam Prices $407.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-BAIAP2 antibody - ab56588 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BAIAP2 antibody [1F4] - ab119183 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1F4

Anti-BAIAP2 / IRSP53 Antibody (aa507-518) - LS-C2961 from LifeSpan Bioscience Prices $285.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (aa350-400) - LS-C203289 from LifeSpan Bioscience Prices $245.00, $325.00 Sizes 40 µg, 100 µg Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, Biotin) - LS-C218683 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, AP) - LS-C218681 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, APC) - LS-C218684 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (aa101-150) - LS-C134908 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, FITC) - LS-C218685 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, Azide-free, HRP) - LS-C218686 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (clone 1037CT15.1.3) - LS-C203924 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 1037CT15.1.3

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus, PE) - LS-C218687 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (clone 3F3-2D3) - LS-C306493 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3F3-2D3

Anti-BAIAP2 / IRSP53 Antibody (aa492-518) - LS-C100956 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody - LS-C309582 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BAIAP2 / IRSP53 Antibody (C-Terminus) - LS-C326909 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Search more