BAIAP2

Gene Symbol	BAIAP2
Entrez Gene	10458
Alt Symbol	BAP2, FLAF3, IRSP53
Species	Human
Gene Type	protein-coding
Description	BAI1-associated protein 2
Other Description	IRS-58|IRSp53/58|brain-specific angiogenesis inhibitor 1-associated protein 2|fas ligand-associated factor 3|insulin receptor substrate p53/p58|insulin receptor substrate protein of 53 kDa
Swissprots	Q53HB1 O43858 Q9UQB8 Q9UBR3 Q86WC1 Q96CR7 Q8N5C0 Q9UQ43
Accessions	BAC57945 BAC57946 BAC57947 BAC57948 EAW89625 EAW89626 EAW89627 EAW89628 Q9UQB8 AB015019 BAA36586 AB015020 BAA36587 AB017119 BAA74773 AB017120 BAA74774 AK023688 AK056888 BAG51821 AK127291 AK222670 BAD96390 AK225612 AK297644 BAG60012 AK298629 BAG60805 AK301436 BAG62963 BC002495 BC014020 AAH14020 BC032559 AAH32559 CB153324 DQ893456 ABM84382 DQ896329 ABM87328 U70669 AAB93497 XM_005256943 XP_005257000 XM_005256944 XP_005257001 XM_005256945 XP_005257002 XM_005256948 XP_005257005 XM_006721635 XP_006721698 XM_006721636 XP_006721699 XM_006721637 XP_006721700 XM_011524193 XP_011522495 XM_011524194 XP_011522496 XM_011524195 XP_011522497 XM_011524196 XP_011522498 XM_011524197 XP_011522499 NM_001144888 NP_001138360 NM_006340 NP_006331 NM_017450 NP_059344 NM_017451 NP_059345
Function	Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Subcellular Location	Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Tissue Specificity	Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. {ECO:0000269|PubMed:10332026, ECO:0000269|PubMed:10343108, ECO:0000269|PubMed:11157984}.
Top Pathways	Adherens junction, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BAI1 associated protein 2 isoform 3 peptide - ab19041 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human BAIAP2 full length protein - ab119452 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human BAIAP2 peptide - ab23256 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human BAIAP2 protein fragment - ab132159 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BAIAP2 / IRSP53 Antibody Blocking Peptide - LS-E10629 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAIAP2 / IRSP53 Antibody Blocking Peptide - LS-E25244 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAIAP2 / IRSP53 Blocking Peptide - LS-E25245 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAIAP2 / IRSP53 Antibody Blocking Peptide - LS-E25246 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAIAP2 / IRSP53 Antibody Blocking Peptide - LS-E9556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAIAP2 Recombinant Protein - H00010458-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human BAIAP2 Protein - NBP1-78872 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

BAIAP2 Peptide - P3222 from Novus Biologicals Category Peptide Species Human

BAIAP2-Antibody-C-term-Blocking-Peptide - BP8174a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BAIAP2 (isoform 1) blocking peptide - GTX15697-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

BAIAP2 (isoform 2) blocking peptide - GTX89261-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

BAIAP2 (isoform 3) blocking peptide - GTX89980-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Human BAIAP2 protein - orb167951 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Goat anti BAIAP2 antibody Immunizing peptide - orb17385 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

BAIAP2 protein (His tag) - 80R-2115 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

BAIAP2 Peptide - AC21-0071-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BAIAP2 Peptide - AC21-0072-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BAIAP2 Peptide - AC21-0073-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BAIAP2 (1-522, His-tag) - AR50198PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

BAIAP2 (1-522, His-tag) - AR50198PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

BAIAP2 - H00010458-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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