BAIAP2

Gene Symbol BAIAP2
Entrez Gene 10458
Alt Symbol BAP2, FLAF3, IRSP53
Species Human
Gene Type protein-coding
Description BAI1-associated protein 2
Other Description IRS-58|IRSp53/58|brain-specific angiogenesis inhibitor 1-associated protein 2|fas ligand-associated factor 3|insulin receptor substrate p53/p58|insulin receptor substrate protein of 53 kDa
Swissprots Q53HB1 O43858 Q9UQB8 Q9UBR3 Q86WC1 Q96CR7 Q8N5C0 Q9UQ43
Accessions BAC57945 BAC57946 BAC57947 BAC57948 EAW89625 EAW89626 EAW89627 EAW89628 Q9UQB8 AB015019 BAA36586 AB015020 BAA36587 AB017119 BAA74773 AB017120 BAA74774 AK023688 AK056888 BAG51821 AK127291 AK222670 BAD96390 AK225612 AK297644 BAG60012 AK298629 BAG60805 AK301436 BAG62963 BC002495 BC014020 AAH14020 BC032559 AAH32559 CB153324 DQ893456 ABM84382 DQ896329 ABM87328 U70669 AAB93497 XM_005256943 XP_005257000 XM_005256944 XP_005257001 XM_005256945 XP_005257002 XM_005256948 XP_005257005 XM_006721635 XP_006721698 XM_006721636 XP_006721699 XM_006721637 XP_006721700 XM_011524193 XP_011522495 XM_011524194 XP_011522496 XM_011524195 XP_011522497 XM_011524196 XP_011522498 XM_011524197 XP_011522499 NM_001144888 NP_001138360 NM_006340 NP_006331 NM_017450 NP_059344 NM_017451 NP_059345
Function Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269|PubMed:11130076, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:14752106, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19366662}.
Subcellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Tissue Specificity Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. {ECO:0000269|PubMed:10332026, ECO:0000269|PubMed:10343108, ECO:0000269|PubMed:11157984}.
Top Pathways Adherens junction, Regulation of actin cytoskeleton

IRSp53 CRISPR/Cas9 KO Plasmid (h) - sc-403072 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 HDR Plasmid (h) - sc-403072-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 Double Nickase Plasmid (h) - sc-403072-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 Double Nickase Plasmid (h2) - sc-403072-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 CRISPR Activation Plasmid (h) - sc-403072-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 CRISPR Activation Plasmid (h2) - sc-403072-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 Lentiviral Activation Particles (h) - sc-403072-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 Lentiviral Activation Particles (h2) - sc-403072-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IRSp53 siRNA (h) - sc-60863 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRSp53 shRNA Plasmid (h) - sc-60863-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IRSp53 shRNA (h) Lentiviral Particles - sc-60863-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BAIAP2 RNAi - H00010458-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU076771 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0153 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0152 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0154 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN3851 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3851 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BAIAP2 siRNA (Human) - CRH7096 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BAIAP2 RNAi - H00010458-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BAIAP2 RNAi - H00010458-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

BAIAP2 - MBS8236961 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BAIAP2 (NM_006340.2) - SHH244750 from Creative biogene

Category siRNA
Species Reactivities Human

BAIAP2 shRNA Plasmid (Human) - CHH7096 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BAIAP2 miRNA 3'UTR clone - MiUTR3H-07710 from Creative biogene

Species Reactivities Human
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