HIPK3

Gene Symbol	HIPK3
Entrez Gene	10114
Alt Symbol	DYRK6, FIST3, PKY, YAK1
Species	Human
Gene Type	protein-coding
Description	homeodomain interacting protein kinase 3
Other Description	ANPK|FIST|androgen receptor-interacting nuclear protein kinase|fas-interacting serine/threonine-protein kinase|homeodomain-interacting protein kinase 3|homolog of protein kinase YAK1
Swissprots	Q92632 O14632 Q9H422 Q2PBG5 Q2PBG4 Q9HAS2
Accessions	EAW68198 EAW68199 Q9H422 AA456456 AF004849 AAC64294 AF305239 AAG25990 AK293009 BAF85698 AK304063 BAG64970 AK315277 AL597397 AW819916 AY425958 AAR07951 BC030112 BC146311 AAI46312 BC156873 AAI56874 BF332205 BX117467 DR000092 HY053621 Y09306 CAA70489 XM_005252729 XP_005252786 XM_011519835 XP_011518137 NM_001048200 NP_001041665 NM_001278162 NP_001265091 NM_001278163 NP_001265092 NM_005734 NP_005725
Function	Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11034606}. Nucleus {ECO:0000269|PubMed:11034606}.
Tissue Specificity	Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung. {ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:9373137, ECO:0000269|PubMed:9725910}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIPK3 (C-14) - sc-46358 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIPK3 (H-80) - sc-66920 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

HIPK3 (K-13) - sc-46359 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIPK3 (N-13) - sc-46360 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HIPK3 antibody - C-terminal - ab151294 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, APC) - LS-C259749 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, Biotin) - LS-C259750 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, FITC) - LS-C259751 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, AP) - LS-C259748 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, Biotin) - LS-C278095 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, Azide-free, HRP) - LS-C259752 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163, PE) - LS-C259753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, FITC) - LS-C278096 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, AP) - LS-C278093 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, APC) - LS-C278094 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, Azide-free, HRP) - LS-C278097 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal, PE) - LS-C278101 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (Internal) - LS-C327562 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1134-1163) - LS-C329623 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa1127-1156) - LS-C99903 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-HIPK3 / FIST Antibody (aa850-900) IHC-plus™ - LS-B1805 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

HIPK3 Antibody - NBP2-24521 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

HIPK3 Antibody - NBP1-84950 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIPK3 Antibody - NBP2-16834 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

HIPK3 Antibody - NBP1-31827 from Novus Biologicals Host Rabbit Clonality Polyclonal

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