| Gene Symbol |
HIPK3
|
| Entrez Gene |
10114
|
| Alt Symbol |
DYRK6, FIST3, PKY, YAK1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
homeodomain interacting protein kinase 3
|
| Other Description |
ANPK|FIST|androgen receptor-interacting nuclear protein kinase|fas-interacting serine/threonine-protein kinase|homeodomain-interacting protein kinase 3|homolog of protein kinase YAK1
|
| Swissprots |
Q92632 O14632 Q9H422 Q2PBG5 Q2PBG4 Q9HAS2
|
| Accessions |
EAW68198 EAW68199 Q9H422 AA456456 AF004849 AAC64294 AF305239 AAG25990 AK293009 BAF85698 AK304063 BAG64970 AK315277 AL597397 AW819916 AY425958 AAR07951 BC030112 BC146311 AAI46312 BC156873 AAI56874 BF332205 BX117467 DR000092 HY053621 Y09306 CAA70489 XM_005252729 XP_005252786 XM_011519835 XP_011518137 NM_001048200 NP_001041665 NM_001278162 NP_001265091 NM_001278163 NP_001265092 NM_005734 NP_005725
|
| Function |
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11034606}. Nucleus {ECO:0000269|PubMed:11034606}.
|
| Tissue Specificity |
Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung. {ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:9373137, ECO:0000269|PubMed:9725910}.
|