HIPK3

Gene Symbol	HIPK3
Entrez Gene	10114
Alt Symbol	DYRK6, FIST3, PKY, YAK1
Species	Human
Gene Type	protein-coding
Description	homeodomain interacting protein kinase 3
Other Description	ANPK|FIST|androgen receptor-interacting nuclear protein kinase|fas-interacting serine/threonine-protein kinase|homeodomain-interacting protein kinase 3|homolog of protein kinase YAK1
Swissprots	Q92632 O14632 Q9H422 Q2PBG5 Q2PBG4 Q9HAS2
Accessions	EAW68198 EAW68199 Q9H422 AA456456 AF004849 AAC64294 AF305239 AAG25990 AK293009 BAF85698 AK304063 BAG64970 AK315277 AL597397 AW819916 AY425958 AAR07951 BC030112 BC146311 AAI46312 BC156873 AAI56874 BF332205 BX117467 DR000092 HY053621 Y09306 CAA70489 XM_005252729 XP_005252786 XM_011519835 XP_011518137 NM_001048200 NP_001041665 NM_001278162 NP_001265091 NM_001278163 NP_001265092 NM_005734 NP_005725
Function	Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11034606}. Nucleus {ECO:0000269|PubMed:11034606}.
Tissue Specificity	Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung. {ECO:0000269|PubMed:11034606, ECO:0000269|PubMed:9373137, ECO:0000269|PubMed:9725910}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human HIPK3 protein fragment - ab85601 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human HIPK3 protein fragment - ab160827 from Abcam Category Protein Source Wheat germ Species Human

Human HIPK3 protein fragment - ab160828 from Abcam Category Protein Source Wheat germ Species Human

HIPK3 / FIST Antibody Blocking Peptide - LS-E9036 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIPK3 Partial Recombinant Protein - H00010114-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HIPK3 Partial Recombinant Protein - H00010114-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HIPK3 Protein - P4700 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

HIPK3 Peptide - P2548 from Novus Biologicals Category Peptide Species Human

HIPK3-Antibody-C-term-Blocking-Peptide - BP7540b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPK3 / FIST / ANPK - H00010114-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HIPK3 / FIST / ANPK - H00010114-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HIPK3 / FIST / ANPK - H00010114-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

HIPK3 / FIST / ANPK - H00010114-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HIPK3 / FIST / ANPK - H00010114-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HIPK3 / FIST / ANPK - P4700 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

HIPK3 / FIST / ANPK - P5719 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

HIPK3 fusion protein - ag20029 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HIPK3 fusion protein - Ag18897 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Homeodomain Interacting Protein Kinase 3 - HIPK3-729H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

HIPK3 Protein, active, 10 µg - 14-680 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg Source expressed by baculovirus in Sf21 cells

HIPK3 Protein, active, 250 µg - 14-680M from EMD Millipore Category Protein Prices $2,543.00 Sizes 250 µg also available in 10 μg size . (cat#14-680) and in bulk (cat#14-680-K) Source expressed by baculovirus in Sf21 cells

Recombinant Human Homeodomain-interacting protein kinase 3(HIPK3) ,partial - CSB-YP872492HU CSB-EP872492HU CSB-BP872492HU CSB-MP872492HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human HIPK3 GST - CSI13415 from Cell Science Prices $615.00 Sizes 10 μg Species Human

HIPK3 Recombinant Protein Antigen - NBP1-84950PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HIPK3-Antibody-Center-Blocking-Peptide - BP7540c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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