Gene Symbol | UBAC1 |
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Entrez Gene | 10422 |
Alt Symbol | GBDR1, UBADC1 |
Species | Human |
Gene Type | protein-coding |
Description | UBA domain containing 1 |
Other Description | E3 ubiquitin-protein ligase subunit KPC2|UBA domain-containing protein 1|glialblastoma cell differentiation-related protein 1|kip1 ubiquitination-promoting complex protein 2|putative glialblastoma cell differentiation-related protein|ubiquitin associated domain containing 1|ubiquitin-associated domain-containing protein 1 |
Swissprots | O75500 Q9UMW7 Q9BSL1 |
Accessions | EAW88187 EAW88188 EAW88189 EAW88190 Q9BSL1 AF038200 AF068195 AAC21559 AF176796 AAD51084 BC004967 AAH04967 BC011822 AAH11822 BX647463 DQ892567 ABM83493 DQ895782 ABM86708 NM_016172 NP_057256 |
Function | Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. {ECO:0000269|PubMed:15531880, ECO:0000269|PubMed:15746103}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10857748, ECO:0000269|PubMed:15531880}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10857748}. |
GBDR1 CRISPR/Cas9 KO Plasmid (h) - sc-409781 from Santa Cruz Biotechnology
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GBDR1 HDR Plasmid (h) - sc-409781-HDR from Santa Cruz Biotechnology
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GBDR1 Double Nickase Plasmid (h) - sc-409781-NIC from Santa Cruz Biotechnology
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GBDR1 Double Nickase Plasmid (h2) - sc-409781-NIC-2 from Santa Cruz Biotechnology
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GBDR1 CRISPR Activation Plasmid (h) - sc-409781-ACT from Santa Cruz Biotechnology
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GBDR1 CRISPR Activation Plasmid (h2) - sc-409781-ACT-2 from Santa Cruz Biotechnology
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GBDR1 Lentiviral Activation Particles (h) - sc-409781-LAC from Santa Cruz Biotechnology
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GBDR1 Lentiviral Activation Particles (h2) - sc-409781-LAC-2 from Santa Cruz Biotechnology
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GBDR1 siRNA (h) - sc-92662 from Santa Cruz Biotechnology
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GBDR1 shRNA Plasmid (h) - sc-92662-SH from Santa Cruz Biotechnology
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GBDR1 shRNA (h) Lentiviral Particles - sc-92662-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU143751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22343 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22343 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03198 from Sigma-Aldrich
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UBAC1 siRNA (Human) - CRH7067 from Cohesion Biosciences
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UBAC1 - MBS8212005 from MyBioSource |
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UBAC1 - MBS8224369 from MyBioSource |
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UBAC1 - MBS8234994 from MyBioSource |
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shRNA set against Human UBAC1 (NM_016172.2) - SHH438720 from Creative biogene
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Human UBAC1 siRNA - orb267569 from Biorbyt
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UBAC1 shRNA Plasmid (Human) - CHH7067 from Cohesion Biosciences
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UBAC1 miRNA 3'UTR clone - MiUTR1H-10923 from Creative biogene
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