| Gene Symbol |
METAP1D
|
| Entrez Gene |
254042
|
| Alt Symbol |
MAP 1D, MAP1D, MetAP 1D, Metap1l
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methionyl aminopeptidase type 1D (mitochondrial)
|
| Other Description |
CDS of metAP-3 within PCR fragment|MAP 1D|metAP 1D|methionine aminopeptidase 1D, mitochondrial|methionyl aminopeptidase type 1D, mitochondrial|peptidase M 1D
|
| Swissprots |
Q6UB28 Q1WNX3
|
| Accessions |
CAG34354 EAX11188 EAX11189 EAX11190 EAX11191 Q6UB28 AK093827 AY374142 AAR27795 BC029123 BC113644 AAI13645 BC143913 DQ005576 AAY55948 XM_011510895 XP_011509197 XM_011510896 XP_011509198 XM_011510897 XP_011509199 XM_011510898 XP_011509200 XM_011510899 XP_011509201 NM_199227 NP_954697
|
| Function |
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16568094}.
|
| Subcellular Location |
Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03174, ECO:0000269|PubMed:14532271}.
|
| Tissue Specificity |
Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). {ECO:0000269|PubMed:16568094}.
|
