Gene Symbol | METAP1D |
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Entrez Gene | 254042 |
Alt Symbol | MAP 1D, MAP1D, MetAP 1D, Metap1l |
Species | Human |
Gene Type | protein-coding |
Description | methionyl aminopeptidase type 1D (mitochondrial) |
Other Description | CDS of metAP-3 within PCR fragment|MAP 1D|metAP 1D|methionine aminopeptidase 1D, mitochondrial|methionyl aminopeptidase type 1D, mitochondrial|peptidase M 1D |
Swissprots | Q6UB28 Q1WNX3 |
Accessions | CAG34354 EAX11188 EAX11189 EAX11190 EAX11191 Q6UB28 AK093827 AY374142 AAR27795 BC029123 BC113644 AAI13645 BC143913 DQ005576 AAY55948 XM_011510895 XP_011509197 XM_011510896 XP_011509198 XM_011510897 XP_011509199 XM_011510898 XP_011509200 XM_011510899 XP_011509201 NM_199227 NP_954697 |
Function | Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis. {ECO:0000255|HAMAP-Rule:MF_03174, ECO:0000269|PubMed:16568094}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03174, ECO:0000269|PubMed:14532271}. |
Tissue Specificity | Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). {ECO:0000269|PubMed:16568094}. |
MAP1D CRISPR/Cas9 KO Plasmid (h) - sc-408352 from Santa Cruz Biotechnology
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MAP1D HDR Plasmid (h) - sc-408352-HDR from Santa Cruz Biotechnology
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MAP1D Double Nickase Plasmid (h) - sc-408352-NIC from Santa Cruz Biotechnology
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MAP1D Double Nickase Plasmid (h2) - sc-408352-NIC-2 from Santa Cruz Biotechnology
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MAP1D CRISPR Activation Plasmid (h) - sc-408352-ACT from Santa Cruz Biotechnology
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MAP1D CRISPR Activation Plasmid (h2) - sc-408352-ACT-2 from Santa Cruz Biotechnology
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MAP1D Lentiviral Activation Particles (h) - sc-408352-LAC from Santa Cruz Biotechnology
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MAP1D Lentiviral Activation Particles (h2) - sc-408352-LAC-2 from Santa Cruz Biotechnology
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MAP1D siRNA (h) - sc-94562 from Santa Cruz Biotechnology
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MAP1D shRNA Plasmid (h) - sc-94562-SH from Santa Cruz Biotechnology
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MAP1D shRNA (h) Lentiviral Particles - sc-94562-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13217 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04451 from Sigma-Aldrich
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METAP1D siRNA (Human) - CRJ6664 from Cohesion Biosciences
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shRNA set against Human METAP1D (NM_199227.1) - SHH340571 from Creative biogene
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shRNA set against Human MAP1D(NM_199227.1) - SHH173045 from Creative biogene
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METAP1D shRNA Plasmid (Human) - CHJ6664 from Cohesion Biosciences
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METAP1D miRNA 3'UTR clone - MiUTR1H-06047 from Creative biogene
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