| Gene Symbol |
GNB4
|
| Entrez Gene |
59345
|
| Alt Symbol |
CMTD1F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein (G protein), beta polypeptide 4
|
| Other Description |
G protein beta-4 subunit|guanine nucleotide-binding protein subunit beta-4|transducin beta chain 4
|
| Swissprots |
D3DNR8 Q9HAV0 B3KMH5
|
| Accessions |
CAE89866 EAW78403 EAW78404 Q9HAV0 AF300648 AAG18442 AK001890 BAG50987 AK022599 AK091332 AK290571 BAF83260 AK297174 BAG59667 AK310009 BC000873 AAH00873 HG496359 HQ447876 ADQ32360 XM_005247692 XP_005247749 XM_006713721 XP_006713784 XM_011513061 XP_011511363 NM_021629 NP_067642
|
| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
|
| Tissue Specificity |
Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. {ECO:0000269|PubMed:11842130, ECO:0000269|PubMed:23434117}.
|
| Top Pathways |
Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse
|