USP44

Gene Symbol	USP44
Entrez Gene	84101
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 44
Other Description	deubiquitinating enzyme 44|ubiquitin carboxyl-terminal hydrolase 44|ubiquitin specific protease 44|ubiquitin thioesterase 44|ubiquitin thiolesterase 44|ubiquitin-specific-processing protease 44
Swissprots	Q9H0E7 B2RDW3
Accessions	EAW97540 EAW97541 EAW97542 Q9H0E7 AA101229 AK027434 AK315697 BAG38060 AL136825 CAB66759 AM392541 CAL37419 BC030704 AAH30704 BI458616 BM023146 DA092275 DB096497 DB443014 DB454726 DB456039 DB462518 DQ890845 ABM81771 DQ893999 ABM84925 EU832278 ACE87535 EU832363 ACE86848 HY021046 XM_005269172 XP_005269229 XM_005269173 XP_005269230 XM_005269174 XP_005269231 XM_006719628 XP_006719691 XM_011538800 XP_011537102 XM_011538801 XP_011537103 XM_011538802 XP_011537104 XM_011538803 XP_011537105 XM_011538804 XP_011537106 XM_011538805 XP_011537107 XM_011538806 XP_011537108 XR_944757 XR_944758 NM_001042403 NP_001035862 NM_001278393 NP_001265322 NM_032147 NP_115523 NR_125360
Function	Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination. {ECO:0000269|PubMed:17443180, ECO:0000269|PubMed:22681888}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20402667}. Note=Peaks in interphase, with relatively low levels maintained throughout mitosis. {ECO:0000250}.
Tissue Specificity	Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia. {ECO:0000269|PubMed:14715245, ECO:0000269|PubMed:21853124}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human USP44 full length protein - ab164494 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human USP44 Protein - H00084101-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

USP44 - H00084101-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

USP44 - H00084101-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

USP44 fusion protein - ag7888 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

USP44 fusion protein - ag5180 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human USP44, GST-tagged - USP44-3630H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 44(USP44) - CSB-YP884431HU CSB-EP884431HU CSB-BP884431HU CSB-MP884431HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

USP44 Blocking Peptide - abx161752 from Abbexa Category Peptide Species Human

USP44 (transcript variant 2) - TP323740 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

USP44 Peptide, Human - M34GP17187H from Creative Peptides Category Peptide Source Synthetic. Species Human

USP44 Blocking Peptide - CBP4541 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

USP44 Blocking Peptide - orb392886 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Human

Search more