| Gene Symbol |
ANKLE2
|
| Entrez Gene |
23141
|
| Alt Symbol |
KIAA0692, LEMD7, Lem4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat and LEM domain containing 2
|
| Other Description |
LEM domain containing 7|LEM domain-containing protein 4|ankyrin repeat and LEM domain-containing protein 2
|
| Swissprots |
Q96DH4 A8KAG3 Q6P6A5 O75176 B3KN97 B3KSF8 Q86XL3 Q8TAZ9
|
| Accessions |
Q86XL3 AB014592 BAA31667 AK024061 BAG51259 AK025933 AK093451 BAG52720 AK293028 BAF85717 BC001530 AAH01530 BC025347 AAH25347 BC043157 AAH43157 BC062373 AAH62373 BC082962 AAH82962 DA757330 DB451935 DB453975 R59085 XM_005266159 XP_005266216 XM_005266160 XP_005266217 XM_005266161 XP_005266218 XM_006719735 XP_006719798 XM_011534787 XP_011533089 XM_011534788 XP_011533090 XM_011534789 XP_011533091 NM_015114 NP_055929
|
| Function |
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. {ECO:0000269|PubMed:22770216}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:22770216}; Single-pass type III membrane protein {ECO:0000269|PubMed:22770216}.
|