Gene Symbol | EDA |
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Entrez Gene | 1896 |
Alt Symbol | ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED |
Species | Human |
Gene Type | protein-coding |
Description | ectodysplasin A |
Other Description | X-linked anhidroitic ectodermal dysplasia protein|ectodysplasin-A|oligodontia 1 |
Swissprots | Q5JUM7 Q9Y6L2 Q92838 B7ZLU2 A2A337 Q5JS00 O75910 Q9Y6L1 Q9UP77 Q9Y6L0 Q9Y6L4 B7ZLU4 Q9Y6L3 A0AUZ2 |
Accessions | AAB65831 AAC50678 EAX05360 EAX05361 EAX05362 Q92838 AF040628 AAC77363 AF060999 AAC36302 AF061189 AAC77371 AF061190 AAC77372 AF061191 AAC77373 AF061192 AAC77374 AF061193 AAC77375 AF061194 AAC77376 AK311532 BC126143 AAI26144 BC144049 AAI44050 BC144051 AAI44052 BE892420 BQ008767 BQ422683 BU608133 CA433299 U59228 AAC50679 XM_006724630 XP_006724693 XM_011530885 XP_011529187 NM_001005609 NP_001005609 NM_001005610 NP_001005610 NM_001005612 NP_001005612 NM_001005613 NP_001005613 NM_001399 NP_001390 NM_001005611 NM_001005614 |
Function | Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
Tissue Specificity | Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. {ECO:0000269|Ref.6}. |
Top Pathways | Cytokine-cytokine receptor interaction |
Human EDA full length protein - ab193871 from Abcam
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Human EDA full length protein - ab195072 from Abcam
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Human EDA protein fragment - ab157273 from Abcam
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EDA / Ectodysplasin A Antibody Blocking Peptide - LS-E16356 from LifeSpan Bioscience
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EDA / Ectodysplasin A Antibody Blocking Peptide - LS-E16357 from LifeSpan Bioscience
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EDA / Ectodysplasin A Antibody Blocking Peptide - LS-E8176 from LifeSpan Bioscience
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EDA/Ectodysplasin Peptide - P1897 from Novus Biologicals
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EDA-Antibody-N-term-Blocking-Peptide - BP6281a from Abgent, a WuXi AppTec company
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Recombinant Human EDA-A1/Ectodysplasin A1 - 3944-ED-010 from R&D Systems
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Recombinant Human EDA-A1/Ectodysplasin A1, CF - 3944-ED-010/CF from R&D Systems
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Recombinant Human EDA-A2 - 922-ED-010 from R&D Systems
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Recombinant Human EDA-A2, CF - 922-ED-010/CF from R&D Systems
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Ectodysplasin A Blocking Peptide - 33R-3477 from Fitzgerald
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Ectodysplasin A Blocking Peptide - 33R-3785 from Fitzgerald
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Ectodysplasin-A - H00001896-H01 from Acris Antibodies
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Ectodysplasin-A - H00001896-H02 from Acris Antibodies
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Recombinant Human Ectodysplasin A, HEK293 Lysate - 230-10052-100 from RayBiotech
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Recombinant Human Ectodysplasin A, HEK293 Transfected Cell Culture Supernatant - 230-20030-200 from RayBiotech
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EDA1 Peptide - 8045P from ProSci
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EDA fusion protein - Ag23153 from Proteintech Group
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EDA fusion protein - Ag23154 from Proteintech Group
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Recombinant Human Ectodysplasin A, FLAG-tagged - EDA-2082H from Creative Biomart
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Recombinant Human Ectodysplasin A, FLAG-tagged - EDA-2117H from Creative Biomart
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Recombinant Human EDA - EDA-260H from Creative Biomart
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Recombinant Ectodysplasin A (EDA) - RPC452Mu01 from Uscn Life Science Inc.
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