| Gene Symbol | EDA |
|---|---|
| Entrez Gene | 1896 |
| Alt Symbol | ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectodysplasin A |
| Other Description | X-linked anhidroitic ectodermal dysplasia protein|ectodysplasin-A|oligodontia 1 |
| Swissprots | Q5JUM7 Q9Y6L2 Q92838 B7ZLU2 A2A337 Q5JS00 O75910 Q9Y6L1 Q9UP77 Q9Y6L0 Q9Y6L4 B7ZLU4 Q9Y6L3 A0AUZ2 |
| Accessions | AAB65831 AAC50678 EAX05360 EAX05361 EAX05362 Q92838 AF040628 AAC77363 AF060999 AAC36302 AF061189 AAC77371 AF061190 AAC77372 AF061191 AAC77373 AF061192 AAC77374 AF061193 AAC77375 AF061194 AAC77376 AK311532 BC126143 AAI26144 BC144049 AAI44050 BC144051 AAI44052 BE892420 BQ008767 BQ422683 BU608133 CA433299 U59228 AAC50679 XM_006724630 XP_006724693 XM_011530885 XP_011529187 NM_001005609 NP_001005609 NM_001005610 NP_001005610 NM_001005612 NP_001005612 NM_001005613 NP_001005613 NM_001399 NP_001390 NM_001005611 NM_001005614 |
| Function | Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. {ECO:0000269|Ref.6}. |
| Top Pathways | Cytokine-cytokine receptor interaction |
EDA CRISPR/Cas9 KO Plasmid (h) - sc-408376 from Santa Cruz Biotechnology
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EDA HDR Plasmid (h) - sc-408376-HDR from Santa Cruz Biotechnology
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EDA Double Nickase Plasmid (h) - sc-408376-NIC from Santa Cruz Biotechnology
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EDA Double Nickase Plasmid (h2) - sc-408376-NIC-2 from Santa Cruz Biotechnology
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EDA CRISPR Activation Plasmid (h) - sc-408376-ACT from Santa Cruz Biotechnology
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EDA CRISPR Activation Plasmid (h2) - sc-408376-ACT-2 from Santa Cruz Biotechnology
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EDA Lentiviral Activation Particles (h) - sc-408376-LAC from Santa Cruz Biotechnology
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EDA Lentiviral Activation Particles (h2) - sc-408376-LAC-2 from Santa Cruz Biotechnology
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EDA siRNA (h) - sc-39825 from Santa Cruz Biotechnology
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EDA shRNA Plasmid (h) - sc-39825-SH from Santa Cruz Biotechnology
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EDA shRNA (h) Lentiviral Particles - sc-39825-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7643 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7643 from Sigma-Aldrich
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EDA siRNA (Human) - CRH1321 from Cohesion Biosciences
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EDA - MBS827628 from MyBioSource
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shRNA set against Human EDA (NM_001399.4) - SHH283037 from Creative biogene
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shRNA set against Human EDA(NM_001005609.1) - SHH023105 from Creative biogene
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shRNA set against Human EDA(NM_001005610.2) - SHH023157 from Creative biogene
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shRNA set against Human EDA(NM_001005609.1) - SHH023175 from Creative biogene
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shRNA set against Human EDA(NM_001399.4) - SHH023195 from Creative biogene
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Human EDA siRNA - orb261823 from Biorbyt
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EDA shRNA Plasmid (Human) - CHH1321 from Cohesion Biosciences
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EDA miRNA 3'UTR clone - MiUTR1H-03098 from Creative biogene
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EDA miRNA 3'UTR clone - MiUTR1H-03099 from Creative biogene
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EDA miRNA 3'UTR clone - MiUTR1H-03100 from Creative biogene
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