| Gene Symbol |
CCL13
|
| Entrez Gene |
6357
|
| Alt Symbol |
CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 13
|
| Other Description |
C-C motif chemokine 13|CK-beta-10|monocyte chemoattractant protein 4|monocyte chemotactic protein 4|new CC chemokine 1|small inducible cytokine subfamily A (Cys-Cys), member 13|small-inducible cytokine A13
|
| Swissprots |
Q99616 Q6ICQ6 O95689
|
| Accessions |
AAB67307 EAW80205 EAW80206 Q99616 AJ001634 CAA04888 BC008621 AAH08621 BT007385 AAP36049 CR450337 CAG29333 DQ891497 ABM82423 DQ894688 ABM85614 U46767 AAB38703 U59808 AAD09362 X98306 CAA66950 Z77650 CAB01111 Z77651 CAB01112 NM_005408 NP_005399
|
| Function |
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|
![Western Blot: MCP4 Overexpression Lysate (Adult Normal) [NBL1-08843] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCP4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1620_MCP4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08843-img0002.jpg)