Gene Symbol | CCL13 |
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Entrez Gene | 6357 |
Alt Symbol | CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 13 |
Other Description | C-C motif chemokine 13|CK-beta-10|monocyte chemoattractant protein 4|monocyte chemotactic protein 4|new CC chemokine 1|small inducible cytokine subfamily A (Cys-Cys), member 13|small-inducible cytokine A13 |
Swissprots | Q99616 Q6ICQ6 O95689 |
Accessions | AAB67307 EAW80205 EAW80206 Q99616 AJ001634 CAA04888 BC008621 AAH08621 BT007385 AAP36049 CR450337 CAG29333 DQ891497 ABM82423 DQ894688 ABM85614 U46767 AAB38703 U59808 AAD09362 X98306 CAA66950 Z77650 CAB01111 Z77651 CAB01112 NM_005408 NP_005399 |
Function | Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. |
Subcellular Location | Secreted. |
Tissue Specificity | Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
MCP-4 CRISPR/Cas9 KO Plasmid (h) - sc-405454 from Santa Cruz Biotechnology
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MCP-4 HDR Plasmid (h) - sc-405454-HDR from Santa Cruz Biotechnology
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MCP-4 Double Nickase Plasmid (h) - sc-405454-NIC from Santa Cruz Biotechnology
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MCP-4 Double Nickase Plasmid (h2) - sc-405454-NIC-2 from Santa Cruz Biotechnology
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MCP-4 CRISPR Activation Plasmid (h) - sc-405454-ACT from Santa Cruz Biotechnology
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MCP-4 CRISPR Activation Plasmid (h2) - sc-405454-ACT-2 from Santa Cruz Biotechnology
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MCP-4 Lentiviral Activation Particles (h) - sc-405454-LAC from Santa Cruz Biotechnology
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MCP-4 Lentiviral Activation Particles (h2) - sc-405454-LAC-2 from Santa Cruz Biotechnology
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MCP-4 siRNA (h) - sc-72122 from Santa Cruz Biotechnology
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MCP-4 shRNA Plasmid (h) - sc-72122-SH from Santa Cruz Biotechnology
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MCP-4 shRNA (h) Lentiviral Particles - sc-72122-V from Santa Cruz Biotechnology
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CCL13/MCP-4 RNAi - H00006357-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5598 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5598 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05008 from Sigma-Aldrich
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CCL13 siRNA (Human) - CRH4290 from Cohesion Biosciences
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CCL13 - MBS8229164 from MyBioSource
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shRNA set against Human CCL13 (NM_005408.2) - SHH257505 from Creative biogene
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Human CCL13 siRNA - orb264792 from Biorbyt
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CCL13 shRNA Plasmid (Human) - CHH4290 from Cohesion Biosciences
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CCL13 miRNA 3'UTR clone - MiUTR1H-01791 from Creative biogene
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