| Gene Symbol |
PAIP2
|
| Entrez Gene |
51247
|
| Alt Symbol |
PAIP-2, PAIP2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(A) binding protein interacting protein 2
|
| Other Description |
PABC1-interacting protein 2|PABP-interacting protein 2|polyA-binding protein-interacting protein 2|polyadenylate-binding protein-interacting protein 2
|
| Swissprots |
Q9H0Y5 Q49A06 B2RBI1 D3DQC6 Q9P0Q8 Q9BPZ3
|
| Accessions |
CAD34710 EAW62107 EAW62108 EAW62109 EAW62110 EAW62111 EAW62112 Q9BPZ3 AF151052 AAF36138 AF317675 AAK11562 AK024552 AK314672 BAG37228 AL136640 CAB66575 AM393698 CAL38574 BC001716 AAH01716 BC039337 AAH39337 BC048106 AAH48106 BC062718 AAH62718 BI552800 BI560379 BU732743 CR533489 CAG38520 DB448759 EU832282 ACE87539 EU832367 ACE86852 XM_011543428 XP_011541730 NM_001033112 NP_001028284 NM_016480 NP_057564 NR_109830
|
| Function |
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. {ECO:0000269|PubMed:11172725}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11172725}.
|
![Western Blot: PAIP2 Overexpression Lysate (Adult Normal) [NBL1-14076] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PAIP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8754_PAIP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14076-img0002.jpg)