| Gene Symbol |
NOC2L
|
| Entrez Gene |
26155
|
| Alt Symbol |
NET15, NET7, NIR, PPP1R112
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleolar complex associated 2 homolog (S. cerevisiae)
|
| Other Description |
NOC2-like protein|novel INHAT (inhibitor of histone acetyltransferase) repressor|novel INHAT repressor|nucleolar complex protein 2 homolog|protein NOC2 homolog|protein phosphatase 1, regulatory subunit 12
|
| Swissprots |
Q9Y3T9 Q5SVA3 Q9BTN6
|
| Accessions |
EAW56304 EAW56305 EAW56306 Q9Y3T9 AK022756 BAB14230 AK024284 BAG51285 AK092491 BAC03905 AK225239 AK315080 AL050019 CAB43240 AM393843 CAL38718 AW749585 BC003555 AAH03555 BC009786 BX645732 DA002961 NM_015658 NP_056473
|
| Function |
Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter. {ECO:0000269|PubMed:16322561, ECO:0000269|PubMed:20123734, ECO:0000269|PubMed:20959462}.
|
| Subcellular Location |
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin- D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
|
