RAB11A

Gene Symbol	RAB11A
Entrez Gene	8766
Alt Symbol	YL8
Species	Human
Gene Type	protein-coding
Description	RAB11A, member RAS oncogene family
Other Description	RAB 11A, member oncogene family|rab-11|ras-related protein Rab-11A
Swissprots	B4DT13 Q9JLX1 B2R4B6 Q5TZN9 P24410 P62491
Accessions	EAW77752 EAW77753 P62491 AF000231 AAC32887 AF498946 AAM21094 AK054930 AK297549 BAG59943 AK298961 BAG61057 AK300008 BAG61825 AK311770 BAG34713 BC013348 AAH13348 BC047114 BI550703 BT020151 AAV38953 BT020154 AAV38956 CR407669 CAG28597 CR536493 CAG38732 DC300743 DQ893054 ABM83980 DQ896303 ABM87302 X53143 CAA37300 X56740 CAA40064 NM_001206836 NP_001193765 NM_004663 NP_004654
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane.
Subcellular Location	Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.
Top Pathways	Endocytosis, Vasopressin-regulated water reabsorption, Pancreatic secretion, Endocrine and other factor-regulated calcium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rab11 (D4F5) XP ® Rabbit mAb - 5589 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (20 western blots) Host Rabbit Clonality Monoclonal Clone D4F5

Rab11 Antibody - 3539 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Rab11a Antibody - 2413 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Rab 11 (C-19) - sc-6565 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rab 11 (H-87) - sc-9020 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Rab 11A (7C10) - sc-58465 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rab 11A (D-3) - sc-166523 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Rab 11A (K-15) - sc-26590 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rab 11A (STo 2F3) - sc-53426 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-Rab11A antibody - ab180778 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Rab11A antibody - ab123365 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Rab11A antibody - ab2921 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-Rab11A antibody [7C10] - ab11034 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 7C10

Anti-Rab11A antibody [EPR7587(B)] - ab128913 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7587(B)

Anti-RAB11A Antibody (aa1-17) - LS-C93526 from LifeSpan Bioscience Prices $485.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (aa1-17) - LS-C131771 from LifeSpan Bioscience Prices $530.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (clone S1) - LS-C139305 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S1

Anti-RAB11A Antibody - LS-C109511 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (Internal, clone EPR7587(B)) - LS-C152460 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7587(B)

Anti-RAB11A Antibody (aa88-116, AP) - LS-C267656 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (aa88-116, APC) - LS-C267657 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (C-Terminus) - LS-C146545 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (C-Terminus) - LS-C146505 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (aa88-116, Biotin) - LS-C267658 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RAB11A Antibody (aa88-116, FITC) - LS-C267659 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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